血浆中性粒细胞明胶酶相关脂质运载蛋白作为造影剂后急性肾损伤早期标志物的研究

IF 0.2 Q4 UROLOGY & NEPHROLOGY
Samad Ghodrati, Seyedeh Masoomeh Mirrajei, N. Parsamanesh, K. Kamali, A. Esmaeilzadeh, A. Pezeshgi
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引用次数: 0

摘要

简介:急性肾损伤(Acute kidney injury, AKI)是住院患者的常见病,其死亡率和发病率均较高。肌酐和中性粒细胞明胶酶相关脂钙蛋白(NGAL)是AKI最常用的生物标志物。目的:本研究的目的是评估NGAL作为对比剂后AKI诊断的早期生物标志物。患者和方法:遵循本病例对照研究的目的,165人进入研究;从赞詹市Valiasr医院选出80名患者,并自愿纳入85名健康个体。健康受试者的性别分布无显著差异。在造影剂暴露前、暴露后12小时和72小时测量血浆NGAL和肌酐。结果:研究组男性89例,女性76例。干预组和健康组的平均年龄分别为61.3±18.2岁和62.1±17.2岁。对照组血清肌酐和NGAL水平均值分别为1.0±0.2 mg/dL和63.6±23.6 ng/mL,病例组分别为0.92±0.23 mg/dL和110±82.3 ng/mL。两组患者血清NGAL、肌酐水平差异有统计学意义。健康组和患者组NGAL水平分别为63.6±23.6 ng/mL和100.1±121.7 ng/mL,与对照组比较差异有统计学意义(P=0.01)。特异性和敏感性最高分别为86和55.5;它们可以作为定义cut - off的主要选项。结论:研究结果表明,NGAL水平是72h后AKI诊断的一个非常特异和敏感的指标。因此,这种方法可以为AKI治疗开辟一个新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of plasma neutrophil gelatinase-associated lipocalin as an early marker of acute kidney injury following contrast agents
Introduction: Acute kidney injury (AKI) is a common illness among hospitalized patients, which increases mortality and morbidity rate. Creatinine and neutrophil gelatinase-associated lipocalin (NGAL) are the most commonly conducted biomarkers of AKI. Objectives: The aim of current study was to assess NGAL as an early biomarker for AKI diagnosis following contrast agents. Patients and Methods: To follow the aim of the present case-control research, 165 individuals were entered the study; 80 patients were selected from Valiasr hospital of Zanjan city, and 85 healthy individuals were enrolled voluntarily. There were not any significant differences in sex distribution among healthy subjects. Plasma NGAL and creatinine were measured immediately before and at 12 and 72 hours post-contrast agents’ exposure. Results: There were 89 males and 76 females in the study groups. The mean age was 61.3 ± 18.2 years and 62.1 ± 17.2 years in the intervention and healthy groups, respectively. The mean of serum creatinine and NGAL level were 1.0± 0.2 mg/dL and 63.6 ±23.6 ng/mL in the control and 0.92 ± 0.23 mg/dL and 110 ± 82.3 ng/mL in the case group, respectively. There were remarkable different between serum NGAL and creatinine in the both groups. The NGAL level in the healthy and the patient group were 63.6 ± 23.6 ng/mL and 100.1 ± 121.7 ng/mL, respectively, which was considerably different between the case and control groups (P=0.01). The highest level of specificity and sensitivity were 86 and 55.5; they could be the main appropriate options for defining cut off. Conclusion: The findings showed, that NGAL level is an extremely specific and sensitive indicator for AKI diagnosis after 72 hours. Hence, this approach can open a novel insight into the AKI therapies.
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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