肿瘤患者亚临床心脏功能障碍1例

Enrique Ruiz-Mori, Leonor Ayala-Bustamante, Edgar Quispe Silvestre, Rowel Rolando Rivas Flores, Jorge Vicente Burgos Bustamante
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En la evaluacion cardiovascular fue asintomatica, con funcion ventricular izquierda normal (60 %), strain disminuido (-15 %) y troponina I elevada (115 ng/mL). Se diagnostico disfuncion cardiaca asintomatica, y se indico carvedilol 6,25 mg/dia. Luego de 3 meses de tratamiento el strain se normalizo (-20 %) y la troponina I (19 ng/mL). Este caso es un ejemplo de la utilidad de las nuevas unidades de cardio-oncologia que permiten evaluar, diagnosticar y tratar precozmente a los pacientes oncologicos, para evitar la cardiotoxicidad y su respectiva mortalidad. EnglishAbstract Cardiotoxicity is a relatively new clinical entity which, in the case of heart failure, is a marker of poor prognosis in cancer survivors who have received more frequent treatments with anthracyclines or trastuzumab. In these patients, detecting a cardiac dysfunction in the subclinical stage can reveal early myocardial involvement and avoid further damage to the heart. 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引用次数: 0

摘要

西班牙心脏毒性是一个相对较新的临床实体,在心力衰竭的情况下,它是癌症幸存者预后不佳的标志,他们更经常接受蒽环类药物或曲妥珠单抗治疗。在这些患者中,亚临床期心脏功能障碍的检测可以早期发现心肌受累,并避免进一步损害心脏。肌钙蛋白I的增加和全球纵向应变等图像的技术进步使检测这种情况成为可能。我们报告一位17岁的左腿骨肉瘤患者接受蒽环类药物治疗的病例。在心血管评估中,它是无症状的,左心室功能正常(60%),应变减少(-15%),肌钙蛋白I升高(115ng/ml)。无症状性心脏功能障碍被诊断出来,卡维地洛为6.25毫克/天。治疗3个月后,应变正常(-20%)和肌钙蛋白I(19 ng/ml)。本例是新的心脏肿瘤单位的一个例子,这些单位可以早期评估、诊断和治疗癌症患者,以避免心脏毒性及其相应的死亡率。Englishabstract心脏毒性是一个相对较新的临床实体,在心力衰竭的情况下,它是癌症幸存者预后不良的标志,他们接受了更频繁的蒽环类药物或曲妥珠单抗治疗。在这些患者中,在亚临床阶段检测到心脏功能障碍可以揭示早期心肌受累,并避免进一步损害心脏。成像技术的进步,如全球纵向应变和肌钙蛋白I的增加,使这种情况得以检测。这份病例报告涉及一名17岁的女性患者,她被诊断出左腿有骨肉瘤,并接受了炭疽治疗。在心血管评估中,她是无症状的,左心室功能正常(60%),应变率降低(-15%),肌钙蛋白I水平升高(115ng/ml)。诊断出无症状性心脏功能障碍,并开了卡维地洛6.25毫克/天的处方。经过3个月的治疗,应变率(-20%)和肌钙蛋白I(19纳克/毫升)水平恢复正常。这是新的心脏肿瘤单位有用的一个例子,这些单位使癌症患者能够及早评估、诊断和治疗,以避免心脏毒性和由此产生的死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disfunción cardiaca subclínica en pacientes oncológicos: reporte de un caso
espanolLa cardiotoxicidad es una entidad clinica relativamente nueva que, en caso de insuficiencia cardiaca, es un marcador de mal pronostico en sobrevivientes de cancer que han recibido, con mayor frecuencia, tratamiento con antraciclinas o trastuzumab. En estos pacientes, la deteccion de la disfuncion cardiaca en estadio subclinico permite descubrir precozmente el compromiso miocardico y evitar un mayor dano al corazon. El incremento de troponina I y los avances tecnologicos en imagenes como el strain longitudinal global permiten detectar esta condicion. Presentamos el caso de una paciente de 17 anos diagnosticada de osteosarcoma en la pierna izquierda y que recibio antraciclinas. En la evaluacion cardiovascular fue asintomatica, con funcion ventricular izquierda normal (60 %), strain disminuido (-15 %) y troponina I elevada (115 ng/mL). Se diagnostico disfuncion cardiaca asintomatica, y se indico carvedilol 6,25 mg/dia. Luego de 3 meses de tratamiento el strain se normalizo (-20 %) y la troponina I (19 ng/mL). Este caso es un ejemplo de la utilidad de las nuevas unidades de cardio-oncologia que permiten evaluar, diagnosticar y tratar precozmente a los pacientes oncologicos, para evitar la cardiotoxicidad y su respectiva mortalidad. EnglishAbstract Cardiotoxicity is a relatively new clinical entity which, in the case of heart failure, is a marker of poor prognosis in cancer survivors who have received more frequent treatments with anthracyclines or trastuzumab. In these patients, detecting a cardiac dysfunction in the subclinical stage can reveal early myocardial involvement and avoid further damage to the heart. Technological advances in imaging, such as the global longitudinal strain, and the increase in troponin I enable the detection of this condition. This case report involves a 17-year-old female patient who was diagnosed with osteosarcoma in her left leg and received anthracyclines. In the cardiovascular evaluation, she was asymptomatic, and showed normal left ventricular function (60 %), decreased strain rate (-15 %) and elevated troponin I levels (115 ng/mL). Asymptomatic cardiac dysfunction was diagnosed and carvedilol 6.25 mg/day was prescribed. After 3 months of treatment, the strain rate (-20 %) and troponin I (19 ng/mL) levels returned to normal. This is an example of the usefulness of new cardiooncology units that allow cancer patients to be evaluated, diagnosed and treated early in order to avoid cardiotoxicity and the resulting mortality.
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