{"title":"肿瘤患者亚临床心脏功能障碍1例","authors":"Enrique Ruiz-Mori, Leonor Ayala-Bustamante, Edgar Quispe Silvestre, Rowel Rolando Rivas Flores, Jorge Vicente Burgos Bustamante","doi":"10.24265/horizmed.2020.v20n1.12","DOIUrl":null,"url":null,"abstract":"espanolLa cardiotoxicidad es una entidad clinica relativamente nueva que, en caso de insuficiencia cardiaca, es un marcador de mal pronostico en sobrevivientes de cancer que han recibido, con mayor frecuencia, tratamiento con antraciclinas o trastuzumab. En estos pacientes, la deteccion de la disfuncion cardiaca en estadio subclinico permite descubrir precozmente el compromiso miocardico y evitar un mayor dano al corazon. El incremento de troponina I y los avances tecnologicos en imagenes como el strain longitudinal global permiten detectar esta condicion. Presentamos el caso de una paciente de 17 anos diagnosticada de osteosarcoma en la pierna izquierda y que recibio antraciclinas. En la evaluacion cardiovascular fue asintomatica, con funcion ventricular izquierda normal (60 %), strain disminuido (-15 %) y troponina I elevada (115 ng/mL). Se diagnostico disfuncion cardiaca asintomatica, y se indico carvedilol 6,25 mg/dia. Luego de 3 meses de tratamiento el strain se normalizo (-20 %) y la troponina I (19 ng/mL). Este caso es un ejemplo de la utilidad de las nuevas unidades de cardio-oncologia que permiten evaluar, diagnosticar y tratar precozmente a los pacientes oncologicos, para evitar la cardiotoxicidad y su respectiva mortalidad. EnglishAbstract Cardiotoxicity is a relatively new clinical entity which, in the case of heart failure, is a marker of poor prognosis in cancer survivors who have received more frequent treatments with anthracyclines or trastuzumab. In these patients, detecting a cardiac dysfunction in the subclinical stage can reveal early myocardial involvement and avoid further damage to the heart. Technological advances in imaging, such as the global longitudinal strain, and the increase in troponin I enable the detection of this condition. This case report involves a 17-year-old female patient who was diagnosed with osteosarcoma in her left leg and received anthracyclines. In the cardiovascular evaluation, she was asymptomatic, and showed normal left ventricular function (60 %), decreased strain rate (-15 %) and elevated troponin I levels (115 ng/mL). Asymptomatic cardiac dysfunction was diagnosed and carvedilol 6.25 mg/day was prescribed. After 3 months of treatment, the strain rate (-20 %) and troponin I (19 ng/mL) levels returned to normal. This is an example of the usefulness of new cardiooncology units that allow cancer patients to be evaluated, diagnosed and treated early in order to avoid cardiotoxicity and the resulting mortality.","PeriodicalId":30557,"journal":{"name":"Horizonte Medico","volume":"20 1","pages":"88-96"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Disfunción cardiaca subclínica en pacientes oncológicos: reporte de un caso\",\"authors\":\"Enrique Ruiz-Mori, Leonor Ayala-Bustamante, Edgar Quispe Silvestre, Rowel Rolando Rivas Flores, Jorge Vicente Burgos Bustamante\",\"doi\":\"10.24265/horizmed.2020.v20n1.12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"espanolLa cardiotoxicidad es una entidad clinica relativamente nueva que, en caso de insuficiencia cardiaca, es un marcador de mal pronostico en sobrevivientes de cancer que han recibido, con mayor frecuencia, tratamiento con antraciclinas o trastuzumab. En estos pacientes, la deteccion de la disfuncion cardiaca en estadio subclinico permite descubrir precozmente el compromiso miocardico y evitar un mayor dano al corazon. El incremento de troponina I y los avances tecnologicos en imagenes como el strain longitudinal global permiten detectar esta condicion. Presentamos el caso de una paciente de 17 anos diagnosticada de osteosarcoma en la pierna izquierda y que recibio antraciclinas. En la evaluacion cardiovascular fue asintomatica, con funcion ventricular izquierda normal (60 %), strain disminuido (-15 %) y troponina I elevada (115 ng/mL). Se diagnostico disfuncion cardiaca asintomatica, y se indico carvedilol 6,25 mg/dia. Luego de 3 meses de tratamiento el strain se normalizo (-20 %) y la troponina I (19 ng/mL). Este caso es un ejemplo de la utilidad de las nuevas unidades de cardio-oncologia que permiten evaluar, diagnosticar y tratar precozmente a los pacientes oncologicos, para evitar la cardiotoxicidad y su respectiva mortalidad. EnglishAbstract Cardiotoxicity is a relatively new clinical entity which, in the case of heart failure, is a marker of poor prognosis in cancer survivors who have received more frequent treatments with anthracyclines or trastuzumab. In these patients, detecting a cardiac dysfunction in the subclinical stage can reveal early myocardial involvement and avoid further damage to the heart. Technological advances in imaging, such as the global longitudinal strain, and the increase in troponin I enable the detection of this condition. This case report involves a 17-year-old female patient who was diagnosed with osteosarcoma in her left leg and received anthracyclines. In the cardiovascular evaluation, she was asymptomatic, and showed normal left ventricular function (60 %), decreased strain rate (-15 %) and elevated troponin I levels (115 ng/mL). Asymptomatic cardiac dysfunction was diagnosed and carvedilol 6.25 mg/day was prescribed. After 3 months of treatment, the strain rate (-20 %) and troponin I (19 ng/mL) levels returned to normal. This is an example of the usefulness of new cardiooncology units that allow cancer patients to be evaluated, diagnosed and treated early in order to avoid cardiotoxicity and the resulting mortality.\",\"PeriodicalId\":30557,\"journal\":{\"name\":\"Horizonte Medico\",\"volume\":\"20 1\",\"pages\":\"88-96\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Horizonte Medico\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24265/horizmed.2020.v20n1.12\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Horizonte Medico","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24265/horizmed.2020.v20n1.12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Disfunción cardiaca subclínica en pacientes oncológicos: reporte de un caso
espanolLa cardiotoxicidad es una entidad clinica relativamente nueva que, en caso de insuficiencia cardiaca, es un marcador de mal pronostico en sobrevivientes de cancer que han recibido, con mayor frecuencia, tratamiento con antraciclinas o trastuzumab. En estos pacientes, la deteccion de la disfuncion cardiaca en estadio subclinico permite descubrir precozmente el compromiso miocardico y evitar un mayor dano al corazon. El incremento de troponina I y los avances tecnologicos en imagenes como el strain longitudinal global permiten detectar esta condicion. Presentamos el caso de una paciente de 17 anos diagnosticada de osteosarcoma en la pierna izquierda y que recibio antraciclinas. En la evaluacion cardiovascular fue asintomatica, con funcion ventricular izquierda normal (60 %), strain disminuido (-15 %) y troponina I elevada (115 ng/mL). Se diagnostico disfuncion cardiaca asintomatica, y se indico carvedilol 6,25 mg/dia. Luego de 3 meses de tratamiento el strain se normalizo (-20 %) y la troponina I (19 ng/mL). Este caso es un ejemplo de la utilidad de las nuevas unidades de cardio-oncologia que permiten evaluar, diagnosticar y tratar precozmente a los pacientes oncologicos, para evitar la cardiotoxicidad y su respectiva mortalidad. EnglishAbstract Cardiotoxicity is a relatively new clinical entity which, in the case of heart failure, is a marker of poor prognosis in cancer survivors who have received more frequent treatments with anthracyclines or trastuzumab. In these patients, detecting a cardiac dysfunction in the subclinical stage can reveal early myocardial involvement and avoid further damage to the heart. Technological advances in imaging, such as the global longitudinal strain, and the increase in troponin I enable the detection of this condition. This case report involves a 17-year-old female patient who was diagnosed with osteosarcoma in her left leg and received anthracyclines. In the cardiovascular evaluation, she was asymptomatic, and showed normal left ventricular function (60 %), decreased strain rate (-15 %) and elevated troponin I levels (115 ng/mL). Asymptomatic cardiac dysfunction was diagnosed and carvedilol 6.25 mg/day was prescribed. After 3 months of treatment, the strain rate (-20 %) and troponin I (19 ng/mL) levels returned to normal. This is an example of the usefulness of new cardiooncology units that allow cancer patients to be evaluated, diagnosed and treated early in order to avoid cardiotoxicity and the resulting mortality.