抗体放射性标记中预靶向策略的研究进展

中华核医学与分子影像杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2020.02.013

Huimin Zhou

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引用次数: 0

摘要

预靶向是一种不同于传统放射性标记抗体成像的成像策略，它将抗体和放射性同位素依次给药，然后通过偶联系统在体内结合。由于耦合系统之间的高特异性和亲和性，放射性同位素在体内定位到靶标上，然后实现放射性标记成像。采用预靶向方法的核成像可以缩短放射性同位素的循环时间，从而减少正常组织对放射性的吸收，便于短寿命放射性同位素的使用。本文综述了生物素-链亲和素(SA)系统、双特异性抗体(BsAb)系统、互补寡核苷酸序列和生物正交点击化学系统等4种主要策略。关键词:放射免疫检测;同位素标记;抗体;趋势

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Research progress of pretargeting strategies in antibody radiolabeling

Pretargeting is an imaging strategy different from the imaging of traditional radiolabeled antibody, in which the antibody and radioisotope are administered in turn and then combined by coupling system within the body. Due to the high specificity and affinity between the coupling systems, the radioisotope is localized to the target in vivo, and then the radioactive labeling is achieved for imaging. Nuclear imaging using pretargeting methods can decrease the circulation duration of the radioisotope so as to reduce the uptake of the radioactivity in normal tissues, and facilitate the use of short-lived radioisotopes. This article provides a bird′s-eye view of 4 main strategies: biotin-streptavidin (SA) system, bispecific antibodies (BsAb) system, complementary oligonucleotides sequence, and bioorthogonal click chemistry system. Key words: Radioimmunodetection; Isotope labeling; Antibodies; Trends

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.