{"title":"慢性乙型肝炎患者乙型肝炎病毒RNA检测的临床价值","authors":"Yu Li, YF Lyu, F. Xi","doi":"10.26689/par.v7i4.4919","DOIUrl":null,"url":null,"abstract":"Objective: To study the clinical value of hepatitis B virus pregenomic RNA (HBV-pgRNA) detection in the treatment of hepatitis B. Methods: 60 patients with hepatitis B were included in the study. Serum HBV-pgRNA and HBV DNA levels in different phases of infection and during treatment were detected, and serum hepatitis B surface antigen (HbsAg) titer was detected by chemiluminescent immunoassay. DNA was extracted from liver biopsy tissue, and covalently closed circular DNA was detected to predict the therapeutic value in patients. Results: At the initial stage of treatment, the level of HBV-pgRNA in phase I, II, III, and IV showed a gradual decrease. Comparing the levels of HBV-pgRNA before and after treatment, we found that the level of HBV-pgRNA was significantly lower after treatment (P < 0.05). Among the indicators for predicting HBsAg seroconversion, the accuracy of HBV-pgRNA level was 85.0% (51/60). Conclusion: The clinical value of HBV-pgRNA detection in the treatment of hepatitis B is high.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Value of Hepatitis B Virus RNA Detection in Patients with Chronic Hepatitis B Infection\",\"authors\":\"Yu Li, YF Lyu, F. Xi\",\"doi\":\"10.26689/par.v7i4.4919\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To study the clinical value of hepatitis B virus pregenomic RNA (HBV-pgRNA) detection in the treatment of hepatitis B. Methods: 60 patients with hepatitis B were included in the study. Serum HBV-pgRNA and HBV DNA levels in different phases of infection and during treatment were detected, and serum hepatitis B surface antigen (HbsAg) titer was detected by chemiluminescent immunoassay. DNA was extracted from liver biopsy tissue, and covalently closed circular DNA was detected to predict the therapeutic value in patients. Results: At the initial stage of treatment, the level of HBV-pgRNA in phase I, II, III, and IV showed a gradual decrease. Comparing the levels of HBV-pgRNA before and after treatment, we found that the level of HBV-pgRNA was significantly lower after treatment (P < 0.05). Among the indicators for predicting HBsAg seroconversion, the accuracy of HBV-pgRNA level was 85.0% (51/60). Conclusion: The clinical value of HBV-pgRNA detection in the treatment of hepatitis B is high.\",\"PeriodicalId\":61025,\"journal\":{\"name\":\"抗癌研究\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"抗癌研究\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.26689/par.v7i4.4919\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"抗癌研究","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26689/par.v7i4.4919","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical Value of Hepatitis B Virus RNA Detection in Patients with Chronic Hepatitis B Infection
Objective: To study the clinical value of hepatitis B virus pregenomic RNA (HBV-pgRNA) detection in the treatment of hepatitis B. Methods: 60 patients with hepatitis B were included in the study. Serum HBV-pgRNA and HBV DNA levels in different phases of infection and during treatment were detected, and serum hepatitis B surface antigen (HbsAg) titer was detected by chemiluminescent immunoassay. DNA was extracted from liver biopsy tissue, and covalently closed circular DNA was detected to predict the therapeutic value in patients. Results: At the initial stage of treatment, the level of HBV-pgRNA in phase I, II, III, and IV showed a gradual decrease. Comparing the levels of HBV-pgRNA before and after treatment, we found that the level of HBV-pgRNA was significantly lower after treatment (P < 0.05). Among the indicators for predicting HBsAg seroconversion, the accuracy of HBV-pgRNA level was 85.0% (51/60). Conclusion: The clinical value of HBV-pgRNA detection in the treatment of hepatitis B is high.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
