2-苯基吡啶衍生物在水中的C-H键官能化的无金属交叉脱氢偶联方法

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Heteroatom Chemistry Pub Date : 2018-07-05 DOI:10.1002/hc.21423

Gogu Venkata Surendra Babu, Parvathaneni Sai Prathima, Pullaiah C. Perumgani, Balasubramanian Sridhar, Tumula Venkateshwar Rao, Mandapati Mohan Rao

引用次数: 3

摘要

我们开发了一个简单的k2s2o8介导的2-苯基吡啶(C-2位)的C- h键功能化与涉及C(sp2)-C(sp3)交叉脱氢偶联的醚。该反应不需要金属催化剂，也不需要可见光，在温和的条件下进行。此外，该协议易于扩展和扩展到广泛的吡啶衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metal-free cross-dehydrogenative coupling approach for C-H bond functionalization of 2-phenyl pyridine derivatives in water

We have developed a simple K₂S₂O₈-mediated C-H bond functionalization of 2-phenyl pyridines (C-2 position) with ethers involving C(sp²)-C(sp³) cross-dehydrogenative coupling. The reaction does not require metal catalysts nor visible light and operates under mild conditions. Furthermore, the protocol is easily scalable and extendable to a wide range of pyridine derivatives.

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来源期刊

Heteroatom Chemistry 化学-化学综合

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Heteroatom Chemistry brings together a broad, interdisciplinary group of chemists who work with compounds containing main-group elements of groups 13 through 17 of the Periodic Table, and certain other related elements. The fundamental reactivity under investigation should, in all cases, be concentrated about the heteroatoms. It does not matter whether the compounds being studied are acyclic or cyclic; saturated or unsaturated; monomeric, polymeric or solid state in nature; inorganic, organic, or naturally occurring, so long as the heteroatom is playing an essential role. Computational, experimental, and combined studies are equally welcome. Subject areas include (but are by no means limited to): -Reactivity about heteroatoms for accessing new products or synthetic pathways -Unusual valency main-group element compounds and their properties -Highly strained (e.g. bridged) main-group element compounds and their properties -Photochemical or thermal cleavage of heteroatom bonds and the resulting reactivity -Uncommon and structurally interesting heteroatom-containing species (including those containing multiple bonds and catenation) -Stereochemistry of compounds due to the presence of heteroatoms -Neighboring group effects of heteroatoms on the properties of compounds -Main-group element compounds as analogues of transition metal compounds -Variations and new results from established and named reactions (including Wittig, Kabachnik–Fields, Pudovik, Arbuzov, Hirao, and Mitsunobu) -Catalysis and green syntheses enabled by heteroatoms and their chemistry -Applications of compounds where the heteroatom plays a critical role. In addition to original research articles on heteroatom chemistry, the journal welcomes focused review articles that examine the state of the art, identify emerging trends, and suggest future directions for developing fields.