阿育吠陀砷制剂Rasamanikya对白化大鼠的遗传毒性潜力评估

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2022-07-15 DOI:10.18311/ti/2022/v29i2/28338

Dipali Parekh, Om Pandey, M. Nariya, Swapnil Chudhri, B. Patgiri

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引用次数: 1

摘要

Shodhita Haratala（加工雌黄）是Rasamanikya（RM）的单一成分。众所周知，如果不按照经典文本进行处理，砷类药物会对人类产生毒性作用，因此，本研究旨在为RM在白化大鼠中的安全性提供数据。本研究采用两种不同的雌黄纯化介质，即青柠汁和石灰水，制备了两种RM样品。堇叶Tinospora cordifolia Linn。（GG）用作佐剂。将RM和GG的两种样品以治疗剂量连续60天给予白化大鼠，在白化大鼠中口服TED（90 mg/kg）和TED×5（450 mg/kg）。RM和GG的样品对白化病大鼠不具有任何诱变或遗传毒性作用。此外，雌黄在更换纯化培养基时的安全性没有发现显著差异。

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Assessment of the Genotoxic Potential of Rasamanikya, an Ayurvedic Arsenical Formulation in Albino Rats

Shodhita Haratala (processed orpiment) is a single ingredient of Rasamanikya (RM). Arsenicals are known for producing toxic effects in humans, if not processed as per classical text therefore, the present study was aim to generate data for the safety of RM in albino rats. In the present study, two samples of RM were prepared by using two different purification media of orpiment, i.e., juice of Benincasa hispida (Thunb.) Cong. and lime water. Extract of Tinospora cordifolia Linn. (GG) was used as an adjuvant. Both the samples of RM along with GG were administered to the albino rats for 60 consecutive days at the therapeutic dose, TED (90 mg/kg) and TED×5 (450 mg/kg) orally in albino rats. Sample of RM along with GG not having the potential to produce any mutagenic or genotoxicity effects in albino rats. Further, there is no significant difference found in the safety of the orpiment on changing of media for purification.

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.