磺胺酸的微波合成

IF 0.7 Q3 MULTIDISCIPLINARY SCIENCES
J. Havlíček, K. Myška, W. Tejchman, N. Karaskova, R. Doležal, Nadezhda V. Maltsevskaya, K. Kolář
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引用次数: 3

摘要

摘要磺胺酸是一种重要的物质,在偶氮染料工业和抗菌剂(如磺胺类药物)的药物开发中经常被使用。学生也可以在化学实验室中遇到这类化合物,例如,当他们用甲基橙指示剂估计pH值或为纺织品染色准备橙II时。这两种染料分别是作为重氮盐的磺胺酸与N,N-二甲基苯胺或2-萘酚偶氮偶联的产物。本文重点介绍了有机化学教学中比较有名的实验——磺胺酸的合成。在半微尺度条件下进行了无溶剂微波辅助实验。该实验对大学或高中有机化学课程的教学非常方便。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microwave synthesis of sulfanilic acid
Abstract Sulfanilic acid represents an important substance, which is frequently utilized in the industry of azo dyes as well as in drug development of antimicrobials (e.g. of sulfonamides). Students can also meet with such type of compounds in chemistry labs, for example, when they estimate pH by methyl orange indicator or prepare Orange II for textile colouring. Both of these dyes are products of azo coupling of sulfanilic acid as diazonium salt with N,N-dimethylaniline or 2-naphthol, respectively. In the article, we focus on the synthesis of sulfanilic acid as a well-known experiment in the organic chemistry education. The synthesis was modified as the solvent free and microwave assisted experiment under semimicroscale conditions. That experiment is very convenient for the organic chemistry courses in the university or the high school teaching.
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来源期刊
Chemistry-Didactics-Ecology-Metrology
Chemistry-Didactics-Ecology-Metrology MULTIDISCIPLINARY SCIENCES-
CiteScore
1.50
自引率
50.00%
发文量
2
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