{"title":"中国维吾尔族癌症患者营养不良的高危因素","authors":"Xiaoru Jiang, Chunhua Song, Hong-xia Xu, Jiu Wei Cui, Yuan Lin, Junqiang Chen, Qingqing Zhao, Zengqing Guo, Kunlun Wang, Ying He, Suyi Li, Hu-sai Ma, Hanping Shi, Jing Wu","doi":"10.34175/jno202104004","DOIUrl":null,"url":null,"abstract":"Abstract: Background Patients with advanced cancer often present with malnutrition. Globally, minority populations frequently suffer from higher rates of malnutrition than the majority group. It was unknown whether the nutritional status of cancer patients is different between ethicality groups (i.e. Uyghur and Han) in China. Methods A total of 251 Uyghur cancer patients were enrolled from the Xinjiang Kashgar First People's Hospital in the INSCOC Program. The Han patients were 1: 1 matched to Uyghur patients by age, gender and type of cancer from 72 hospitals around China in INSCOC Program. The nutritional risk and nutritional status were assessed using the Nutrition Risk Screening 2002 (NRS 2002) and Patient-Generated Subjective Global Assessment (PG-SGA), respectively. Then, the functional status of cancer patients was determined based on the Karnofsky Performance Status (KPS). Results The incidence of an abnormal NRS-2002 (≥ 3), PG-SGA (≥ 4), and KPS (≤ 70) was significantly different (86.1% vs 59.0%, 70.5% vs 27.5%, and 18.7% vs 4.0%, respectively P < 0.05). The abnormal rate of laboratory indicators in Uyghur cancer patients was significantly higher than that in Han cancer patients, including total protein, albumin, serum total bilirubin, direct bilirubin, HDL-C, white blood cell, lymphocyte, red blood cell, and platelet (all P < 0.05). The abnormal rates of TSF, HGS and CC were significantly higher than that of Han nationality patients (17.5% vs 9.7%, 39.6% vs 19.6%, 29.1% vs 15.2%, P < 0.001). The nutritional support rate of Uyghur patients was lower than that of Han patients (0% vs 16.3%). After adjusting for potential risk factors, malnutrition was associated with gender (female, OR = 0.35, 95% CI = 0.13-0.92, P = 0.034), age (> 60 years, OR = 5.32, 95% CI = 1.46-19.41, P = 0.011), cancer type (gastroesophageal tumor, OR = 33.62, 95% CI = 3.42-330.67, P = 0.003), and treatment methods (received radical tumor resection, OR = 5.78, 95% CI = 1.45-23.08, P = 0.008; received radiotherapy or chemotherapy: OR = 7.69, 95% CI = 2.27-26.04, P < 0.001). Conclusions The nutritional status of Uyghur cancer patients is worse than that of Han patients and the Uyghur patients with poor nutritional status lack the necessary nutritional support.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"176 - 185"},"PeriodicalIF":0.0000,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High Risk of Malnutrition in Uyghur Patients with Cancer in China\",\"authors\":\"Xiaoru Jiang, Chunhua Song, Hong-xia Xu, Jiu Wei Cui, Yuan Lin, Junqiang Chen, Qingqing Zhao, Zengqing Guo, Kunlun Wang, Ying He, Suyi Li, Hu-sai Ma, Hanping Shi, Jing Wu\",\"doi\":\"10.34175/jno202104004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: Background Patients with advanced cancer often present with malnutrition. Globally, minority populations frequently suffer from higher rates of malnutrition than the majority group. It was unknown whether the nutritional status of cancer patients is different between ethicality groups (i.e. Uyghur and Han) in China. Methods A total of 251 Uyghur cancer patients were enrolled from the Xinjiang Kashgar First People's Hospital in the INSCOC Program. The Han patients were 1: 1 matched to Uyghur patients by age, gender and type of cancer from 72 hospitals around China in INSCOC Program. The nutritional risk and nutritional status were assessed using the Nutrition Risk Screening 2002 (NRS 2002) and Patient-Generated Subjective Global Assessment (PG-SGA), respectively. Then, the functional status of cancer patients was determined based on the Karnofsky Performance Status (KPS). Results The incidence of an abnormal NRS-2002 (≥ 3), PG-SGA (≥ 4), and KPS (≤ 70) was significantly different (86.1% vs 59.0%, 70.5% vs 27.5%, and 18.7% vs 4.0%, respectively P < 0.05). The abnormal rate of laboratory indicators in Uyghur cancer patients was significantly higher than that in Han cancer patients, including total protein, albumin, serum total bilirubin, direct bilirubin, HDL-C, white blood cell, lymphocyte, red blood cell, and platelet (all P < 0.05). The abnormal rates of TSF, HGS and CC were significantly higher than that of Han nationality patients (17.5% vs 9.7%, 39.6% vs 19.6%, 29.1% vs 15.2%, P < 0.001). The nutritional support rate of Uyghur patients was lower than that of Han patients (0% vs 16.3%). After adjusting for potential risk factors, malnutrition was associated with gender (female, OR = 0.35, 95% CI = 0.13-0.92, P = 0.034), age (> 60 years, OR = 5.32, 95% CI = 1.46-19.41, P = 0.011), cancer type (gastroesophageal tumor, OR = 33.62, 95% CI = 3.42-330.67, P = 0.003), and treatment methods (received radical tumor resection, OR = 5.78, 95% CI = 1.45-23.08, P = 0.008; received radiotherapy or chemotherapy: OR = 7.69, 95% CI = 2.27-26.04, P < 0.001). Conclusions The nutritional status of Uyghur cancer patients is worse than that of Han patients and the Uyghur patients with poor nutritional status lack the necessary nutritional support.\",\"PeriodicalId\":64349,\"journal\":{\"name\":\"Journal of Nutritional Oncology\",\"volume\":\"6 1\",\"pages\":\"176 - 185\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nutritional Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.34175/jno202104004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutritional Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.34175/jno202104004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
摘要:背景晚期癌症患者常表现为营养不良。在全球范围内,少数群体的营养不良率往往高于多数群体。目前尚不清楚中国不同民族(即维吾尔族和汉族)癌症患者的营养状况是否存在差异。方法入选INSCOC项目新疆喀什第一人民医院维吾尔族肿瘤患者251例。在INSCOC项目中,汉族患者与维吾尔族患者在年龄、性别和癌症类型上的比例为1:1。分别采用营养风险筛查2002 (NRS 2002)和患者主观整体评估(PG-SGA)对营养风险和营养状况进行评估。然后,根据Karnofsky Performance status (KPS)来确定癌症患者的功能状态。结果NRS-2002异常(≥3)、PG-SGA异常(≥4)、KPS异常(≤70)的发生率分别为86.1% vs 59.0%、70.5% vs 27.5%、18.7% vs 4.0%,差异有统计学意义(P < 0.05)。维吾尔族肿瘤患者总蛋白、白蛋白、血清总胆红素、直接胆红素、HDL-C、白细胞、淋巴细胞、红细胞、血小板等实验室指标异常率显著高于汉族肿瘤患者(P < 0.05)。TSF、HGS、CC异常率显著高于汉族(17.5% vs 9.7%, 39.6% vs 19.6%, 29.1% vs 15.2%, P < 0.001)。维族患者的营养支持率低于汉族患者(0% vs 16.3%)。校正潜在危险因素后,营养不良与性别(女性,OR = 0.35, 95% CI = 0.13-0.92, P = 0.034)、年龄(50 - 60岁,OR = 5.32, 95% CI = 1.46-19.41, P = 0.011)、肿瘤类型(胃食管肿瘤,OR = 33.62, 95% CI = 3.42-330.67, P = 0.003)、治疗方法(接受根治性肿瘤切除术,OR = 5.78, 95% CI = 1.45-23.08, P = 0.008;接受放疗或化疗:or = 7.69, 95% CI = 2.27-26.04, P < 0.001)。结论维吾尔族癌症患者的营养状况较汉族患者差,营养状况差的维吾尔族患者缺乏必要的营养支持。
High Risk of Malnutrition in Uyghur Patients with Cancer in China
Abstract: Background Patients with advanced cancer often present with malnutrition. Globally, minority populations frequently suffer from higher rates of malnutrition than the majority group. It was unknown whether the nutritional status of cancer patients is different between ethicality groups (i.e. Uyghur and Han) in China. Methods A total of 251 Uyghur cancer patients were enrolled from the Xinjiang Kashgar First People's Hospital in the INSCOC Program. The Han patients were 1: 1 matched to Uyghur patients by age, gender and type of cancer from 72 hospitals around China in INSCOC Program. The nutritional risk and nutritional status were assessed using the Nutrition Risk Screening 2002 (NRS 2002) and Patient-Generated Subjective Global Assessment (PG-SGA), respectively. Then, the functional status of cancer patients was determined based on the Karnofsky Performance Status (KPS). Results The incidence of an abnormal NRS-2002 (≥ 3), PG-SGA (≥ 4), and KPS (≤ 70) was significantly different (86.1% vs 59.0%, 70.5% vs 27.5%, and 18.7% vs 4.0%, respectively P < 0.05). The abnormal rate of laboratory indicators in Uyghur cancer patients was significantly higher than that in Han cancer patients, including total protein, albumin, serum total bilirubin, direct bilirubin, HDL-C, white blood cell, lymphocyte, red blood cell, and platelet (all P < 0.05). The abnormal rates of TSF, HGS and CC were significantly higher than that of Han nationality patients (17.5% vs 9.7%, 39.6% vs 19.6%, 29.1% vs 15.2%, P < 0.001). The nutritional support rate of Uyghur patients was lower than that of Han patients (0% vs 16.3%). After adjusting for potential risk factors, malnutrition was associated with gender (female, OR = 0.35, 95% CI = 0.13-0.92, P = 0.034), age (> 60 years, OR = 5.32, 95% CI = 1.46-19.41, P = 0.011), cancer type (gastroesophageal tumor, OR = 33.62, 95% CI = 3.42-330.67, P = 0.003), and treatment methods (received radical tumor resection, OR = 5.78, 95% CI = 1.45-23.08, P = 0.008; received radiotherapy or chemotherapy: OR = 7.69, 95% CI = 2.27-26.04, P < 0.001). Conclusions The nutritional status of Uyghur cancer patients is worse than that of Han patients and the Uyghur patients with poor nutritional status lack the necessary nutritional support.