多发性骨髓瘤细胞外囊泡及其microRNA研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.12.018

Xu Lu

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引用次数: 0

摘要

多发性骨髓瘤(Multiple myeloma, MM)是血液系统常见病，多见于中老年人群。MM的发病机制尚不清楚，目前还不能完全治愈。近年来研究发现，microRNA (miRNA)在MM的发生发展中起着关键作用，MM细胞还能释放胞外囊泡(EV)，参与细胞间信息传递和调控。本文就EV在MM发生发展中的作用作一综述。关键词:多发性骨髓瘤;细胞外囊泡;液;小分子核糖核酸

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Progress of extracellular vesicle and its microRNA in multiple myeloma

Multiple myeloma (MM) is a common disease in the blood system, which mostly occurs in the middle-aged and the senior people. The pathogenesis of MM is not clear and MM can not be completely cured at present. Recent studies have found that microRNA (miRNA) plays a key role in the occurrence and development of MM. In addition, MM cells can release extracellular vesicle (EV), and involve in the intercellular information transmission and regulation. This paper reviews the role of EV in the development of MM. Key words: Multiple myeloma; Extracellular vesicle; Exosomes; MicroRNAs

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.