姜黄甲醇提取物的生物活性检测及其对金黄色葡萄球菌的抗菌作用

IF 1.2 Q3 MULTIDISCIPLINARY SCIENCES
C. Ogbonna, Erkay Özgör
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引用次数: 1

摘要

摘要众所周知,植物具有巨大而深远的好处,如果能很好地融入日常生活,就有可能以意想不到的方式影响我们的健康。在食品中生物活性成分的抗氧化和抗癌作用方面取得了重大进展,值得注意的是从姜黄(Curcuma longa)根茎中提取的姜黄素类化合物。因此,本研究旨在简要介绍姜黄甲醇提取物的植物成分、抗氧化活性和抗微生物活性。在Mueller-Hinton琼脂平板上平板后测量抑制区,并与标准青霉素G和氯霉素进行比较。作为阳性对照的氯霉素对金黄色葡萄球菌最有效,而姜黄甲醇提取物和青霉素G由于阴性对照而具有相同的微生物抑制作用。与抗坏血酸的IC50值为5mg/ml相比,姜黄甲醇提取物的IC50较低,为3.2mg/ml,根据先前的文献,这是一个好的值,因为较低的IC50数值表明具有良好的抗氧化活性。通过观察发现,使用甲醇定性提取姜黄显示出不同化学成分的存在,如AR肿瘤酮、花生黄、α肿瘤酮等。研究数据表明,ar姜黄酮具有促进肿瘤细胞系正、负增殖的潜力。因此,姜黄在未来发展成为对抗耐甲氧西林金黄色葡萄球菌和其他临床重要菌株的抗生素具有很高的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Detection of Biological Activity of Curcuma longa Methanol Extract and Its Antibacterial effect on Staphylococcus aureus
Abstract Plants are known to possess enormous profound benefits, which if well incorporated in daily living have the potential to influence our health in ways unexpected. Significant progress has been made concerning the anti-oxidative and anti-cancerous effect of bioactive components in food products, worthy of note in the curcuminoids derived from turmeric (Curcuma longa) rhizomes. Therefore, to this end, this research aims to describe succinctly the phytocomponents, antioxidant activity and anti-microbial activity of turmeric methanol extract. The zones of inhibition were measured after plating on a Mueller Hinton agar plate and compared to the standards penicillin G and chloramphenicol. Chloramphenicol used as a positive control was found to be most effective on Staphylococcus aureus while Curcuma longa methanol extract and penicillin G were found to have the same microbial inhibition due to the negative control. Compared to the IC50 values of Ascorbic acid which was 5 mg/ ml, Curcuma longa methanol extract had a lower IC50 value is 3.2 mg/ml which according to previous literature is a good one given that lower IC50 values indicate great antioxidant activity. It was gathered by the observation that the qualitative extraction of Curcuma longa using methanol shows the presence of varying chemical components such as AR-tumerone, arachinsaeure, alpha-tumerone amongst others. Research data suggest that ar-turmerone has the potential to promote the positive and negative proliferation of tumor cell lines. As a result, Curcuma longa has high potential to be developed into an antibiotic against Methicillin-resistant Staphylococcus aureus and other clinically important bacterial strains in future.
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来源期刊
The EuroBiotech Journal
The EuroBiotech Journal Agricultural and Biological Sciences-Food Science
CiteScore
3.60
自引率
0.00%
发文量
17
审稿时长
10 weeks
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