急性乙型肝炎康复者免疫缺陷综合征

A. Kanatbekova
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摘要

背景。慢性乙型肝炎(CHB)仍然是现代医学中最紧迫的问题之一。全世界约有2.96亿慢性乙型肝炎患者,每年有82万人死于肝硬化和肝细胞癌。目标。探讨急性乙型肝炎(AHB)恢复期免疫缺陷综合征的特点。材料和方法。我们研究了104例AHB恢复期免疫缺陷综合征(IDS),对照组由78例表面健康的供者组成。所有被调查者的年龄都在18-45岁之间。根据Acad. R.V. Petrov(1987)开发的IDS地图对IDS进行了研究。结果。17.3%的AHB恢复期患者没有IDSs,而82.7%的AHB恢复期患者至少检测到三种IDSs(感染性、特应性和自身免疫性)中的一种。在44.2%的病例中,有一种IDS的临床变异,34.9%的病例有两种综合征,20.9%的病例有三种综合征同时以不同的组合出现。AHB合并IDS的康复过程不顺利或疾病转变为慢性过程的患者占24.4%,而对照组的这一比例为12.3%。结论。AHB合并IDS应纳入进行性形式,即作为肝硬化和肝癌发展的高危病理,从而确定其适当的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IMMUNODEFICIENCY SYNDROMES IN ACUTE HEPATITIS B CONVALESCENTS
Background. Chronic hepatitis B (CHB) remains one of the most urgent problems in modern medicine. There are about 296 million people with CHB worldwide, 820 thousand dying annually of liver cirrhosis and hepatocellular carcinoma. Objective. To study the immunodeficiency syndrome peculiarities in acute hepatitis B (AHB) convalescents. Material and methods. We have studied immunodeficiency syndrome (IDS) in 104 AHB convalescents, the control group comprised 78 apparently healthy donors. All examined were between the ages 18-45. IDSs were studied according to the IDS Map developed by Acad. R.V. Petrov (1987). Results. In 17.3% of AHB convalescent patients IDSs were absent, while in 82.7% - at least one of the three IDSs (infectious, atopic and autoimmune) was detected. In 44.2% of cases, clinical variants of one IDS were noted, in 34.9% - those of two syndromes, in 20.9% - those of three syndromes simultaneously in various combinations. Convalescence from AHB with IDS either had a non-smooth course or the disease transformed into a chronic process in 24.4%, while in the control group - in 12.3% of cases. Conclusions. AHB with IDS should be included in the progredient form, i.e. as a high-risk pathology of liver cirrhosis and hepatocarcinoma development, thus determining its appropriate therapeutic strategy.
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