Clinical and Experimental Study on Probiotics in the Treatment of Constipation Type Irritable Bowel Syndrome

Aim: The effects of probiotics on symptoms scores, gastrointestinal hormones and oxidative stress index in constipative Irritable Bowel Syndrome (IBS-C) patients were studied-during the period of 2018. Methods: 96 patients with IBS-C who had been treated in our hospital previously. The patients in the control group (49) were treated with Mosapride, and the patients in the observation group (47) were treated with Bifidobacterium triple viable enteric-coated capsules on the basis of the control treatment. The clinical efficacy including: clinical symptoms, gastrointestinal hormones, 5-HT and oxidative stress were studied and compared between the two groups. Results: In the observation group, the clinical efficacy in 29 cases (61.70%) was markedly effective and in 15 cases (31.91%) moderately effective, in comparison the total effective rate was 93.62%in the observation group, and 79.59% in the control group (P < 0.05). After treatment, the clinical symptoms score in both two groups decreased significantly. The scores of abdominal distension, abdominal pain, defecation frequency, stool characteristics and defecation difficulty in the observation group were significantly lower than those in the control group (P < 0.05). Although the levels of 5-HT, MDA and LPO in both groups decreased significantly after treatment. The levels of 5-HT, MDA and LPO in the observation group were even lower than those in the control group (P < 0.05). Similarly, the levels of gastrointestinal hormones in both groups were improved with the respective treatments. However, the MTL level in the observation group was significant higher than that in the control group, and the levels of VIP and S were lower in the observation group than those in the control group (P < 0.05). Conclusion: Bifidobacterium triple viable capsule combined with Mosapride is more effective in the treatment of IBS-C. The combination therapy can better relieve symptoms, and further decreased gastrointestinal hormone levels and reduce oxidative stress response in IBS-C patients. It is therefore highly recommended for clinical application.