高、低级别轴内脑肿瘤MRS影像学指标与组织学的比较

Q4 Medicine

Romanian Journal of Neurology/ Revista Romana de Neurologie Pub Date : 2022-09-30 DOI:10.37897/rjn.2022.3.3

Varun Singh Pendro, Jyothish Ls, Darpan Kaur, Saurabh Sharma

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引用次数: 0

摘要

的目标。本研究的目的是比较高级别和低级别脑轴内肿瘤的MRS成像肿瘤指数与组织学。患者和方法。这项前瞻性观察性研究包括30例在蒂鲁万anthapuram政府医学院神经外科接受轴内脑胶质瘤手术的患者，为期1年。结论是基于脑MRI扫描(普通+对比)与MRS和组织学检查得出的。结果。n -乙酰天冬氨酸(NAA)、胆碱(Cho)、肌酐(Cr) 3种代谢物共振归一化面积值在低级别胶质瘤和高级别胶质瘤之间有统计学意义(p<0.05)。Cho/NAA和Cho/Cr在区分低级胶质瘤和高级胶质瘤方面也存在显著差异。结论。本研究表明，Cho/NAA和Cho/Cr比值是肿瘤分级的可靠决定因素，具有良好的敏感性和特异性。因此，MRS的Cho/NAA和Cho/Cr比值可作为鉴别低级别胶质瘤和高级别胶质瘤的诊断工具。

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Comparison of MRS imaging tumor index among high and low grade intra axial brain tumor with histology

Aim. The aim of this study was to compare the MRS imaging tumor index among high-grade and low-grade intra axial brain tumor with histology. Patients and methods. This prospective observational study consisted of 30 patients who underwent surgery for intra-axial brain glioma in the Department of Neurosurgery, Government Medical College, Thiruvananthapuram in a 1 year duration. Inferences were drawn based on MRI scans of brain (plain + contrast) with MRS and a histological examination. Results. The normalized area values of 3 metabolite resonances, namely N-Acetyl Aspartate (NAA), Choline (Cho) and Creatinine (Cr), between low grade glioma and high-grade glioma were found to be statistically significant (p<0.05). Significant difference was also present among Cho/NAA and Cho/Cr in differentiating low-grade from high-grade glioma. Conclusion. This study has shown that Cho/NAA and Cho/Cr ratios are reliable determinants of the tumor grade with good sensitivity and specificity. Thus, Cho/NAA and Cho/Cr ratios of MRS maybe used as a diagnostic tool in differentiating low grade gliomas from high grade gliomas.

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来源期刊

Romanian Journal of Neurology/ Revista Romana de Neurologie Medicine-Neurology (clinical)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.