Omentin-1通过AMPK功能抑制NLRP3的炎症

IF 0.1 4区 生物学 Q4 GENETICS & HEREDITY
Yong Jiang
{"title":"Omentin-1通过AMPK功能抑制NLRP3的炎症","authors":"Yong Jiang","doi":"10.31901/24566330.2022/22.03.830","DOIUrl":null,"url":null,"abstract":"This experiment investigated the biological roles of Omentin-1 in cerebral vessels of acute cerebral ischemia (ACI). The expressions of Omentin-1 in mouse model or patients with ACI were down-regulated. Moreover, Omentin-1 was negatively correlated with NIHSS score or serum IL-1β expression in patients undergoing intravenous thrombolysis for ACI. Omentin-1 was positively correlated with Barthel index in patients undergoing intravenous thrombolysis for ACI. In the mouse model or the in-vitro model, Omentin-1 mitigated inflammation factors. Additionally, in the in-vitro model of ACI, overexpression of Omentin-1 induced AMPK/ NLRP3 signaling pathway. Down-regulation of Omentin-1 also inhibited AMPK/ NLRP3 signaling pathway. Taken together, Omentin-1 suppressed ACI in the ACI model through inhibiting inflammation, which might serve as a potential treatment strategies of cardiovascular and cerebrovascular diseases in ACI.","PeriodicalId":54956,"journal":{"name":"International Journal of Human Genetics","volume":null,"pages":null},"PeriodicalIF":0.1000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Omentin-1 Suppressed Inflammation by NLRP3 through AMPK Function\",\"authors\":\"Yong Jiang\",\"doi\":\"10.31901/24566330.2022/22.03.830\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This experiment investigated the biological roles of Omentin-1 in cerebral vessels of acute cerebral ischemia (ACI). The expressions of Omentin-1 in mouse model or patients with ACI were down-regulated. Moreover, Omentin-1 was negatively correlated with NIHSS score or serum IL-1β expression in patients undergoing intravenous thrombolysis for ACI. Omentin-1 was positively correlated with Barthel index in patients undergoing intravenous thrombolysis for ACI. In the mouse model or the in-vitro model, Omentin-1 mitigated inflammation factors. Additionally, in the in-vitro model of ACI, overexpression of Omentin-1 induced AMPK/ NLRP3 signaling pathway. Down-regulation of Omentin-1 also inhibited AMPK/ NLRP3 signaling pathway. Taken together, Omentin-1 suppressed ACI in the ACI model through inhibiting inflammation, which might serve as a potential treatment strategies of cardiovascular and cerebrovascular diseases in ACI.\",\"PeriodicalId\":54956,\"journal\":{\"name\":\"International Journal of Human Genetics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Human Genetics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.31901/24566330.2022/22.03.830\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Human Genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.31901/24566330.2022/22.03.830","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

摘要

本实验研究了Omentin-1在急性脑缺血(ACI)脑血管中的生物学作用。Omentin-1在小鼠模型或ACI患者中的表达下调。此外,在接受ACI静脉溶栓治疗的患者中,Omentin-1与NIHSS评分或血清IL-1β表达呈负相关。在接受ACI静脉溶栓治疗的患者中,Omentin-1与Barthel指数呈正相关。在小鼠模型或体外模型中,Omentin-1减轻了炎症因子。此外,在ACI的体外模型中,Omentin-1的过表达诱导了AMPK/NLRP3信号通路。下调Omentin-1也抑制AMPK/NLRP3信号通路。总之,在ACI模型中,Omentin-1通过抑制炎症来抑制ACI,这可能是ACI中心脑血管疾病的一种潜在治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Omentin-1 Suppressed Inflammation by NLRP3 through AMPK Function
This experiment investigated the biological roles of Omentin-1 in cerebral vessels of acute cerebral ischemia (ACI). The expressions of Omentin-1 in mouse model or patients with ACI were down-regulated. Moreover, Omentin-1 was negatively correlated with NIHSS score or serum IL-1β expression in patients undergoing intravenous thrombolysis for ACI. Omentin-1 was positively correlated with Barthel index in patients undergoing intravenous thrombolysis for ACI. In the mouse model or the in-vitro model, Omentin-1 mitigated inflammation factors. Additionally, in the in-vitro model of ACI, overexpression of Omentin-1 induced AMPK/ NLRP3 signaling pathway. Down-regulation of Omentin-1 also inhibited AMPK/ NLRP3 signaling pathway. Taken together, Omentin-1 suppressed ACI in the ACI model through inhibiting inflammation, which might serve as a potential treatment strategies of cardiovascular and cerebrovascular diseases in ACI.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
37
审稿时长
>12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信