核磁共振工具破译RNA的动态结构

IF 0.4 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of the Korean magnetic resonance society Pub Date : 2017-06-20 DOI:10.6564/JKMRS.2017.21.2.055

Janghyun Lee, Byong-Seok Choi

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引用次数: 0

摘要

RNA在调节细胞过程中发挥着基本作用，这一点现在已经得到了很好的证实。这些RNA中的许多并不存在于单一构象中。相反，它们在许多不同构象之间进行动态转换，以介导与其他生物分子（如蛋白质、RNA、DNA或小分子）的关键相互作用。在这里，我们简要回顾了通过确定结构、动力学和热力学性质来描述RNA动态行为的NMR技术。

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NMR Tools to Decipher Dynamic Structure of RNA

It is now well established that RNAs exhibit fundamental roles in regulating cellular processes. Many of these RNAs do not exist in a single conformation. Rather, they undergo dynamic transitions among many different conformations to mediate critical interactions with other biomolecules such as proteins, RNAs, DNAs, or small molecules. Here, we briefly review NMR techniques that describe the dynamic behavior of RNA by determining structural, kinetic, and thermodynamic properties.

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来源期刊

Journal of the Korean magnetic resonance society BIOCHEMICAL RESEARCH METHODS-

自引率

66.70%

发文量