Anti Depression Potential of Papaya Seed Extracts in Wistar Rat Models

The purpose of this study is to evaluate the potential of papaya seed extract as an antidepressant based on body weight, glucose levels, Interleukin-6, and malondialdehyde levels in treated rats. Force swimming and tail suspension tests have been conducted to measure acute stress and evaluate response behavior. Results showed that the higher concentration of papaya seed extract correlates to higher effectivity on reducing body weight and lowering glucose levels. Dose-response relationships were also observed on the inhibition effect of interleukin-6 and malondialdehyde more effective at higher extract concentrations. The experimental force swimming test and tail suspension test showed the positive effect of extract administration indicated by the shorter immobilization time. Gas chromatography analysis has confirmed the bioactive content in the extract. The main compounds such as; 9-Octadecenoic acid (Z)-methyl ester, Benzyl nitrile, Hexadecanoic acid- methyl ester, and other saponins might be responsible for the antidepressant effects of papaya seed extract. This research encourages further studies on pharmacodynamics, pharmacokinetics, and biomolecules analysis at cellular levels.