缺血性卒中吸入性取栓术中吸力-吸力距离关系的计算流体动力学研究

Q3 Medicine
Yubing Shi , David Cheshire , Frank Lally , Christine Roffe
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引用次数: 22

摘要

急性缺血性脑卒中(Acute Ischemic Stroke, AIS)是发生在患者中的主要脑卒中类型。吸入性取栓术是一种利用吸力清除血栓形成的技术,是临床上治疗AIS患者的一种很有前途的技术。在这项研究中,计算流体动力学(CFD)分析进行了模拟在一个简化的脑模型在吸入性取栓过程中的血流动力学。所分析的血流系统是一个典型的体外脑血流模型,系统参数是根据公开文献报道的临床和体外数据设置的。模拟的流场特征与文献报道的体外反应具有良好的相关性。CFD研究提供了详细的技术数据,包括导管尖端出现的峰值速度和吸力-吸力距离在吸入性取栓过程中的关系,这是有用的新知识,有可能影响未来的导管设计以及在取栓干预过程中使用的临床操作方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study

Acute Ischemic Stroke (AIS) is the major type of stroke occurring in patients. Aspiration thrombectomy, which uses suction to remove the thrombosis, is a promising technique in the clinical treatment of AIS patients. In this research a computational fluid dynamics (CFD) analysis was conducted to model the blood flow dynamics in a simplified cerebral model during an aspiration thrombectomy procedure. The flow system being analysed was a typical in vitro cerebral flow model, and the system parameters were set based on the clinical and in vitro data reported in open literature. The simulated flow field features showed good correlation with the in vitro response as reported in literature. The CFD study provides detailed technical data including the peak velocity occurring at the catheter tip and the suction force-suction distance relation during the aspiration thrombectomy procedure, which are useful new knowledge and have the potential to influence future catheter design as well as clinical operational protocols used during thrombectomy intervention.

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来源期刊
Physics in Medicine
Physics in Medicine Physics and Astronomy-Instrumentation
CiteScore
2.60
自引率
0.00%
发文量
9
审稿时长
12 weeks
期刊介绍: The scope of Physics in Medicine consists of the application of theoretical and practical physics to medicine, physiology and biology. Topics covered are: Physics of Imaging Ultrasonic imaging, Optical imaging, X-ray imaging, Fluorescence Physics of Electromagnetics Neural Engineering, Signal analysis in Medicine, Electromagnetics and the nerve system, Quantum Electronics Physics of Therapy Ultrasonic therapy, Vibrational medicine, Laser Physics Physics of Materials and Mechanics Physics of impact and injuries, Physics of proteins, Metamaterials, Nanoscience and Nanotechnology, Biomedical Materials, Physics of vascular and cerebrovascular diseases, Micromechanics and Micro engineering, Microfluidics in medicine, Mechanics of the human body, Rotary molecular motors, Biological physics, Physics of bio fabrication and regenerative medicine Physics of Instrumentation Engineering of instruments, Physical effects of the application of instruments, Measurement Science and Technology, Physics of micro-labs and bioanalytical sensor devices, Optical instrumentation, Ultrasound instruments Physics of Hearing and Seeing Acoustics and hearing, Physics of hearing aids, Optics and vision, Physics of vision aids Physics of Space Medicine Space physiology, Space medicine related Physics.
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