Efficacy of Work-Related Support Rehabilitation for Patients with Cancer: A Meta-Analysis of Randomized Controlled Trials

Abstract Introduction The efficacy of work-related support rehabilitation for patients with cancer remains controversial. We conduct a systematic review and meta-analysis to explore the influence of work-related support rehabilitation on the quality of life in patients with cancer. Methods We have searched Pubmed, Embase, Web of science, Ebsco, and Cochrane library databases through August 2021 for randomized controlled trials (RCTs) assessing the effect of work-related support rehabilitation on the quality of life in patients with cancer. This meta-analysis is performed using the random-effect model. Results Four RCTs are included in the meta-analysis. Overall, compared with usual care for cancer patients, work-related support is associated with significantly improved quality of life physical score (PCS, standard mean difference [SMD]=0.22; 95% confidence interval [CI]=0.06 to 0.37; P=0.005) and reduced quality of life pain (SMD=−0.16; 95% CI=−0.31 to 0; P=0.04), but showed no obvious impact on quality of life mental score (MCS, SMD=0; 95% CI=−0.28 to 0.28; P=0.98), time of return to work (SMD=−0.78; 95% CI=−2.71 to 1.14; P=0.43), or the scores of work ability (SMD=−0.01; 95% CI=−0.16 to 9.09; P=0.13) and work limitation (SMD=0.12; 95% CI=−0.16 to 0.40; P=0.41). Conclusions Work-related support rehabilitation may be effective to improve the quality of life of cancer patients.