Camphoric酸均手性季溴铵的合成、聚集及抗菌性能的相关性研究

European Pharmaceutical Journal Pub Date : 2021-01-01 DOI:10.2478/afpuc-2020-0017

R. Mikláš, N. Miklášová, M. Bukovský

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引用次数: 0

摘要

摘要合成了一类含疏水樟脑酸衍生基团的同手性季铵盐，并对其进行了表征。通过表面张力测试评价了所制备化合物的聚集性能，并计算了临界胶束浓度(CMC)。对新型季铵盐作为抗菌和抗真菌药物进行了测试，并对其最小抑制浓度(MIC)进行了评估，并与临床使用的苯扎溴铵(BAB)进行了比较。MIC与CMC的相关性表明，制备的阳离子表面活性剂的单体，而不是胶束，主要负责抗菌活性。

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Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid

Abstract A group of homochiral quaternary ammonium salts bearing hydrophobic camphoric acid-derived moiety was synthesized and characterized. The aggregation properties of the prepared compounds were evaluated by surface tension measurements, and the critical micelle concentration (CMC) was calculated. The novel quaternary ammonium bromides were tested as antimicrobial and antifungal agents, and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB). Correlation of MIC with CMC reveals that monomers of prepared cationic surfactants, instead of micelles, are primarily responsible for antimicrobial activity.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.