多形性轻疹的临床病理研究

N. Patil, A. Bubna, Maharaja Krishnamoorthy, L. Joseph
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摘要

背景:多形性光疹(PLE)是最常见的特发性光损伤性疾病,临床表现广泛,往往与多种皮肤病相似。目的:研究诊断为PLE的患者的临床病理特征。材料和方法:这是一项在一年内对70例临床诊断的PLE病例进行的横断面描述性研究,其中在患者入组后,他们接受了彻底的临床评估,然后进行了明确研究的皮肤活检。结果:男性占优势(62.8%)。大多数患者在21-30岁年龄组(28.6%)。98.5%的患者出现瘙痒。最常见的形态类型是斑块PLE(35.7%),其次是nitidus型地衣(11.4%)。最常见的受累部位是颈部两侧和后部(75.7%),然后是双臂背外侧(31.4%)。角化过度占82.8%,海绵状血管病占87.1%,基底细胞层液化性变性占82.8%。萎缩占24.2%,在我们90%的队列中有中度至重度淋巴细胞性真皮浸润。结论:PLE是一种临床表现多样的疾病,通常在生命的第三个十年表现出来,与其他各种皮肤疾病非常相似。具有某些特定标准的组织学检查使临床医生能够在仅凭临床发现造成诊断困难的情况下得出具体结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A clinicopathological study of polymorphous light eruption
Background: Polymorphous light eruption (PLE) is the most common idiopathic photodermatoses, with a wide range of clinical presentations that tends to mimic a number of dermatoses. Objective: The aim was to study the clinicopathological profile in patients diagnosed with PLE. Materials and Methods: This was a cross-sectional, descriptive study of seventy clinically diagnosed cases of PLE over a period of 1 year, wherein following patient enrolment, they underwent a thorough clinical evaluation, followed by a skin biopsy that was studied categorically. Results: A male preponderance (62.8%) was observed. Majority of patients were in the 21-30 years' age group (28.6%). Pruritus was witnessed in 98.5% of patients. The most common morphological type encountered was plaque PLE (35.7%), followed by lichen nitidus type (11.4%). Commonest site of involvement was sides and back of neck (75.7%), followed by dorsolateral aspect of both arms (31.4%). Hyperkeratosis was identified in 82.8%, spongiosis in 87.1%, liquefactive degeneration of basal cell layer in 82.8%, atrophy in 24.2%, and moderate-to-severe lymphocytic dermal infiltrates in 90% of our cohorts. Conclusion: PLE is a disorder with diverse clinical presentations, manifesting usually in the third decade of life that closely mimics a variety of other cutaneous disorders. Histological examination with certain specific criteria enables the clinician to arrive at a concrete conclusion in those cases where clinical findings alone pose diagnostic difficulties.
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