套筒胃切除术对糖尿病和非糖尿病病态肥胖患者肾功能的影响

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2022-05-31 DOI:10.34172/jrip.2022.32028

Z. Davoudi, N. Zahed, Sahab-sadat Tabatabaei, Y. Farsi, Mohsen Soori, S. Mirhashemi

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引用次数: 0

摘要

引言：肥胖与蛋白尿和肾功能受损有关。减肥手术已被证明可以改善和解决糖尿病，并改善病态肥胖患者的肾功能。本研究探讨了袖状胃切除术对改善糖尿病和非糖尿病病态肥胖患者肾功能和蛋白尿的潜在影响，并讨论了可能的机制。材料和方法：这项前瞻性研究包括137名接受腹腔镜袖状胃切除术的病态肥胖患者（44名糖尿病患者和93名非糖尿病患者），他们在手术前和手术后1年接受了临床（人体测量）和生化评估。结果：袖状胃切除术显著降低糖尿病和非糖尿病患者的体重和体重指数，改善血糖参数、高滤过率和尿白蛋白排泄；（P＜0.001）。C反应蛋白（CRP）水平的改变与糖尿病患者ACR的下降密切相关。结论：我们的研究结果显示，糖尿病和非糖尿病患者在袖状胃切除术后，体重、体重指数和血糖参数显著降低，同时通过减少全身炎症来解决高滤过、尿白蛋白排泄和改善肾功能。

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The effects of sleeve gastrectomy on renal function in diabetic and non-diabetic morbidly obese patients

Introduction: Obesity is associated with albuminuria and impaired renal function. Bariatric surgery has been shown to improve and resolve diabetes and improve renal function in patients with morbid obesity. This study investigates the potential effects of sleeve gastrectomy on the improvement of renal function and albuminuria in diabetic and non-diabetic morbidly obese patients and discusses probable mechanisms. Material and methods: This prospective study included, 137 morbidly obese patients (44 diabetics and 93 non-diabetic) who underwent laparoscopic sleeve gastrectomy who were evaluated clinically (anthropometric measurements) and biochemically before surgery and at 1 year from surgery. Results: Sleeve gastrectomy significantly decreases weight and body mass index, improves glycemic parameters, hyperfiltration, and urinary albumin excretion in diabetic and non-diabetic patients; (P < 0.001). Alterations in C- reactive protein (CRP) levels are strongly associated with ACR decline in diabetic patients. Conclusion: Our findings revealed significant decreases in weight, body mass index, and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, accompanied by the resolve of hyperfiltration, urinary albumin excretion, and improvement of renal function via reduction of the systemic inflammation.

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.