癌症非洲黑人女性月经周期分期对生物物理和生化参数的影响

Q4 Medicine

Rwanda Medical Journal Pub Date : 2022-06-30 DOI:10.4314/rmj.v79i2.3

O. Ajayi, M. Charles-Davies, J. I. Inetor, A. Ademola

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引用次数: 0

摘要

简介：许多关于癌症女性患者的研究在收集血液样本进行实验室调查时没有考虑卵泡期和黄体期之间的差异。因此，本研究旨在研究月经周期各阶段对生殖激素和甲状腺激素、内分泌干扰物、血压和身体肥胖的影响。方法：参与者（n=107），年龄28-50岁，包括54例新诊断的癌症患者（例为月经期，年龄与53例看似健康但未患癌症的女性相匹配，作为对照）。获取人体测量指标和血压（BP）。血清激素雌二醇、孕酮、黄体生成素（LH）、游离三碘甲状腺原氨酸（FT3）、促甲状腺激素（TSH）、促卵泡激素（FSH）和游离甲状腺素（FT4）通过酶免疫测定进行定量。采用原子吸收分光光度法对内分泌干扰物砷、铅和镉进行了定量分析。使用Student t检验和Pearson相关系数对数据进行分析，p＜0.05被认为是显著的。结果：黄体期和卵泡期的体重、臀围、腰围和FT3各不相同，病例高于对照组。在两个阶段，病例的ED均显著高于对照组。与卵泡病例和对照相比，黄体病例和对照组的孕酮、雌二醇和LH水平显著较高。与卵泡对照组相比，黄体对照组的FT3显著降低。在病例和对照组的每个阶段，肥胖测量值、血压、ED和激素之间存在显著的正相关和负相关。结论：月经周期似乎会影响乳腺正常和癌变女性的血压、肥胖程度、内分泌干扰物和生殖激素。这需要在采集血样以研究这些参数时加以考虑。

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Effect of phases of the menstrual cycle on biophysical and biochemical parameters of African black women with breast cancer

INTRODUCTION: Many studies on female breast cancer patients do not consider the differences between the follicular and luteal phases when collecting blood samples for laboratory investigations. Therefore, this study was designed to investigate the effects of the phases of the menstrual cycle on reproductive and thyroid hormones, endocrine disruptors, blood pressure, and body adiposity. METHODS: Participants (n=107) aged 28-50 years, comprising 54 newly diagnosed breast cancer patients (cases were menstrual phase and age-matched to 53 seemingly healthy women without breast cancer that served as controls. Anthropometric indices and blood pressure (BP) were obtained. Serum hormones-estradiol, progesterone, luteinizing hormone (LH), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), stimulating follicle hormone (FSH), and free thyroxine (FT4) were quantified by enzyme immunoassay. Endocrine disruptors (EDs)- arsenic, lead and cadmium were quantified by atomic absorption spectrophotometry (AAS). Data were analyzed using Student’s t-test and Pearson correlation coefficient with p<0.05 considered significant. RESULTS: Bodyweight, hip circumference, waist-height ratio, and FT3 varied between the luteal and follicular phases, higher in cases than controls. EDs were significantly higher in cases than controls in both phases. Progesterone, estradiol and LH levels were significantly higher in luteal cases and controls when compared with follicular cases and controls.FT3 was significantly lower in luteal controls compared with follicular controls. There were significant direct and inverse correlations among adiposity measures, BP, EDs, and hormones in each phase in both cases and controls. CONCLUSION: The menstrual cycle appears to influence blood pressure, measures of adiposity, endocrine disruptors, and reproductive hormones in women with normal and cancerous breasts. This requires consideration in the collection of blood samples for investigations of these parameters.

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来源期刊

Rwanda Medical Journal Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： The Rwanda Medical Journal (RMJ), is a Not-For-Profit scientific, medical, journal that is published entirely online in open-access electronic format. The RMJ is an interdisciplinary research journal for publication of original work in all the major health disciplines. Through a rigorous process of evaluation and peer review, The RMJ strives to publish original works of high quality for a diverse audience of healthcare professionals. The Journal seeks to deepen knowledge and advance scientific discovery to improve the quality of care of patients in Rwanda and internationally.