快速应用长效头孢噻呋可预防猪中马链球菌亚种动物流行病相关的死亡损失

IF 0.7 4区 农林科学 Q3 Agricultural and Biological Sciences
Samantha J. Hau, A. Buckley, S. Brockmeier
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引用次数: 0

摘要

目的:将马链球菌亚种动物流行病菌株引入原始种群,在5至10天内可导致30%至50%的田间死亡率。由于疾病进展迅速,我们的目标是确定抗生素干预是否可以在临床症状发展后控制一组动物的S型动物流行病。材料与方法:用马疫亚种攻击32头猪。随着临床症状的发展,16人接受了长效注射用头孢噻呋的治疗。七头未受挑战的猪作为对照。激发后监测临床症状,并比较各组的生存率。在激发后第0天和第30天测量抗体滴度。在攻击后第30天,将3头接触猪与2只处理过的动物混合,以评估马疫亚种的传播。结果:头孢噻呋治疗消除了16只动物中15只的临床症状。然而,需要多种治疗来控制治疗动物的疾病(2-3剂,覆盖12-18天)。在接受头孢噻呋治疗的受攻击动物中,对马兽疫亚种的抗体滴度增加,表明有足够的免疫刺激暴露。没有接触过的猪在接触后出现马疫亚种的临床症状。含义:快速应用注射抗生素是一种可行的方法,可以减少由于将马疫亚种引入一组幼稚的猪中而造成的损失,并可能有助于防止康复后传播给接触动物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rapid application of long-acting ceftiofur can prevent death losses associated with Streptococcus equi subspecies zooepidemicus in pigs
Objective: Introduction of Streptococcus equi subspecies zooepidemicus strains into naive populations results in field mortality rates of 30% to 50% over 5 to 10 days. Because of the rapid disease progression, our goal was to determine whether antibiotic intervention could control S zooepidemicus disease in a group of animals following development of clinical signs. Materials and methods: Thirty-two pigs were challenged with S equi subsp zooepidemicus. Following the development of clinical signs, 16 were treated with long-acting, injectable ceftiofur. Seven unchallenged pigs served as controls. Clinical signs were monitored following challenge and survival was compared between groups. Antibody titers were measured on day 0 and day 30 post challenge. On day 30 post challenge, 3 contact pigs were commingled with 2 treated animals to evaluate S equi subsp zooepidemicus transmission. Results: Ceftiofur treatment eliminated clinical signs in 15 of 16 animals. However, multiple treatments were required to control disease in treated animals (2-3 doses providing 12-18 days of coverage). Antibody titers to S equi subsp zooepidemicus increased in challenged animals treated with ceftiofur, indicating sufficient exposure for immune stimulation. No contact pigs developed clinical signs of S equi subsp zooepidemicus following exposure. Implication: Rapid application of injectable antibiotics is a viable method to reduce losses due to the introduction of S equi subsp zooepidemicus into a naive group of pigs and may help prevent transmission to contact animals following recovery.
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
29
审稿时长
>36 weeks
期刊介绍: The Journal of Swine Health & Production (JSHAP) is an open-access and peer-reviewed journal published by the American Association of Swine Veterinarians (AASV) since 1993. The aim of the journal is the timely publication of peer-reviewed papers with a scope that encompasses the many domains of applied swine health and production, including the diagnosis, treatment, management, prevention and eradication of swine diseases, welfare & behavior, nutrition, public health, epidemiology, food safety, biosecurity, pharmaceuticals, antimicrobial use and resistance, reproduction, growth, systems flow, economics, and facility design. The journal provides a platform for researchers, veterinary practitioners, academics, and students to share their work with an international audience. The journal publishes information that contains an applied and practical focus and presents scientific information that is accessible to the busy veterinary practitioner as well as to the research and academic community. Hence, manuscripts with an applied focus are considered for publication, and the journal publishes original research, brief communications, case reports/series, literature reviews, commentaries, diagnostic notes, production tools, and practice tips. All manuscripts submitted to the Journal of Swine Health & Production are peer-reviewed.
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