回到基础:地中海贫血和携带者人口管理的三个适婚行动

IF 0.6 Q4 HEMATOLOGY
Sehjeong Kim, Hamda AlDhaheri, So-Yeun Kim
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引用次数: 0

摘要

我们调查了三种适婚行为:正常对携带者、携带者对正常和携带者对携带者婚姻对地中海贫血和携带者人群的影响。众所周知的策略是限制携带者与携带者的婚姻,以减少地中海贫血的人口。因此,其他两项适婚行为往往被忽视。除了简单解释它们的遗传后果外,它们在地中海贫血遗传机制中的重要方面从未在群体层面进行过研究。此外,还没有一个数学模型来研究人群水平上对血液疾病感兴趣的问题。因此,我们开发了一个数学模型,以检验通过三种适婚行为中的每一种长期消除/减少地中海贫血和携带者群体的可能性。我们用阿拉伯联合酋长国的人口统计数据进行了计算机模拟,在这些数据中,地中海贫血携带者的患病率很高。我们发现,促进更多的携带者向正常婚姻转变,最终会对携带者夫妇的婚姻重新考虑产生同样的影响,从长远来看,有助于减少携带者人口。有趣的是,正常与携带者的婚姻对地中海贫血和携带者人群的影响并不一定与携带者与正常婚姻相似。因此,这两项适婚行动应加以区分,并在地中海贫血的教育和公众宣传运动中予以认真考虑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Going Back to Fundamentals: Three Marriageable Actions for Thalassemia and Carrier Population Management
We investigated the impact of three marriageable actions: normal-to-carrier, carrier-to-normal, and carrier-to-carrier marriages on thalassemia and carrier populations. The well-known strategy is limiting the carrier-to-carrier marriage to reduce the thalassemia population. Thus, the other two marriageable actions were often ignored. Other than a simple explanation of their genetic consequences, their important aspect in the thalassemia inheritance mechanism has never been studied at the population level. Moreover, there is no mathematical model investigating problem of interest for blood disorders at the population level. Hence, we developed a mathematical model to examine the possibility of eradication/reduction of thalassemia and carrier populations through each of the three marriageable actions in the long-term. We conducted computer simulations with the demographic data of the United Arab Emirates in which high thalassemia carrier prevalence is identified. We found that promoting more carrier-to-normal marriage will eventually have the same effects on marriage reconsideration for carrier-carrier couples, contributing to the reduction of the carrier population in the long-term. Interestingly, the normal-to-carrier marriage does not necessarily have a similar effect on thalassemia and carrier populations as that of the carrier-to-normal marriage. Thus, the two marriageable actions should be distinguished and also seriously considered in education and public awareness campaigns for thalassemia.
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来源期刊
Thalassemia Reports
Thalassemia Reports HEMATOLOGY-
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