宿主代谢琥珀酸盐摄取与沙门氏菌毒力诱导的相关性

Q4 Immunology and Microbiology

Journal of Bacteriology and Virology Pub Date : 2021-03-01 DOI:10.4167/JBV.2021.51.1.037

Y. Choi, Y. Koh

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引用次数: 0

摘要

这是一篇基于知识共享署名非商业许可协议(http://creativecommons.org/ License /by-nc/3.0/)的开放获取文章。在细胞内感染过程中，琥珀酸盐的积累促进了沙门氏菌的致病程序。采用RNA-seq方法，在含琥珀酸的培养基中检测pmrAB和沙门氏菌致病性岛2 (SPI-2)调控基因mRNA表达的增加。此外，通过DcuB转运体摄取宿主代谢性琥珀酸盐也诱导了沙门氏菌毒力的程序。因此，琥珀酸盐是引起肠炎沙门氏菌血清型鼠伤寒沙门氏菌毒力的主要因素。

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Uptake of Host Metabolic Succinate Correlates with Salmonella Virulence Induction

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ license/by-nc/3.0/). Accumulation of succinate promotes Salmonella pathogenic program during intracellular infection. Using RNA-seq, increased mRNA expression of the genes in pmrAB and Salmonella pathogenicity island2 (SPI-2) regulon is measured in succinate-containing medium. Furthermore, uptake of host metabolic succinate through DcuB transporter also induces program for Salmonella virulence. Thus, succinate is major factor of Salmonella enterica serovar Typhimurium (S.Tm) virulence induction.

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来源期刊

Journal of Bacteriology and Virology Immunology and Microbiology-Immunology

CiteScore

0.80

自引率

0.00%

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