急性淋巴细胞白血病患儿血清淋巴增强因子结合因子-1水平及其与临床血液学和预后参数的关系

IF 0.1 Q4 HEMATOLOGY
Zeena Ahmed, A. Ahmed
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引用次数: 1

摘要

背景:急性淋巴母细胞白血病(Acute lymphoblastic leukemia, ALL)是一种异质性疾病,其特征是未成熟淋巴样细胞增生,在骨髓、外周血和髓外部位积聚,导致该疾病的临床表现。淋巴增强因子-1 (Lymphoid enher -binding factor-1, LEF1)是wingless型信号通路的靶基因和中枢介质,在正常造血中具有重要作用。据报道,在许多类型的血液和非血液恶性肿瘤中,LEF1的高表达是一种预后标志物。研究目的:评估小儿ALL患者血清LEF1水平及其与其他血液学和临床预后因素(白细胞计数、年龄、性别、中枢神经系统受累和对治疗的反应)的相关性。患者、材料和方法:这项横断面研究对60名儿童进行了研究;20例开始诱导治疗前新诊断的ALL患者,20例缓解期ALL患者(诱导后),20例健康对照。采用酶联免疫吸附法测定血清LEF1水平。结果:新诊断患者血清LEF1水平高于缓解期患者和对照组,且差异极显著。与白细胞总数有显著正相关,LEF1水平与其他血液学和临床参数及免疫表型亚型无显著相关。血清LEF1水平与缓解诱导反应无显著相关性。结论:初诊ALL患者血清中LEF1浓度较高,且与WBC总计数呈显著正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of serum level of lymphoid enhancer-binding factor-1 and its relation with clinico-hematological and prognostic parameters in pediatric patients with acute lymphoblastic leukemia
BACKGROUND: Acute lymphoblastic leukemia (ALL) is a heterogeneous disorder characterized by the proliferation of immature lymphoid cells that accumulate in the bone marrow, peripheral blood, and extramedullary sites, causing the clinical manifestations of the disease. Lymphoid enhancer-binding factor-1 (LEF1) is a target gene and central mediator for the Wingless-type signaling pathway, and it has an important role in normal hematopoiesis. High LEF1 expression was reported as a prognostic marker in many types of hematological and nonhematological malignancies. AIM OF THE STUDY: To evaluate the serum level of LEF1 in pediatric patients with ALL and its correlation with other hematological and clinical prognostic factors (white blood cells [WBC] count, age, gender, central nervous system involvement, and response to treatment). PATIENTS, MATERIALS, AND METHODS: This cross-sectional study was conducted on 60 children; 20 patients with newly diagnosed ALL before starting induction therapy, 20 patients with ALL during remission (postinduction), and 20 healthy controls. Measurement of serum LEF1 level was done by enzyme-linked immunosorbent assay. RESULTS: Serum level of LEF1 was higher in newly diagnosed patients than in either patients at remission or controls with highly significant differences. There is a significant positive correlation with total WBC count and no significant correlation between LEF1 level and other hematological and clinical parameters or with immunophenotypic subtypes. There was no significant correlation between LEF1 serum level and response to remission induction. CONCLUSION: A high serum concentration of LEF1 is found in newly diagnosed patients with ALL and showed a significant positive correlation with total WBC count.
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