视黄醇棕榈酸酯对皮肤结构的主要影响及其在皮肤科实践中的应用技术

Q4 Medicine
S. Petrova, V. Albanova, K. V. Nozdrin, K. S. Guzev
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引用次数: 0

摘要

维生素A及其合成类似物被用于治疗多种皮肤病。天然形式的维生素A(视黄醇棕榈酸酯)的主要基因组效应与其活性代谢物全反式维甲酸有关,并由几种限制性机制补偿。大量研究证明,视黄醇能刺激表皮基底层角质形成细胞和内皮细胞的增殖,并能激活真皮成纤维细胞合成真皮细胞外基质蛋白。因此,增厚的表皮,增加了皮肤的机械强度和真皮的补水能力,血管生成增加。视黄醇能够增强内皮细胞和白细胞的粘附,调节角化过程和皮脂分泌。维生素A也是一种强大的抗氧化剂。视黄醇棕榈酸酯被用作治疗多种皮肤病的主要或辅助药物。应用原理以临床研究为基础,并得到现有实验数据的证实。在处理中,遵循以下算法。如果棕榈酸视黄醇是改善上皮化和加强表皮屏障所必需的,则应使用中等治疗剂量。对于角化过程疾病的治疗,根据病理状况的严重程度,使用中剂量和高剂量的药物。皮脂分泌过程的破坏和严重角化过度对高治疗剂量的治疗反应更好。应该指出的是,许多皮肤的临床表现大多在维生素A的作用下消退,剂量不会导致药物毒性迹象的出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Main effects of retinol palmitate on skin structures and the technology of its use in dermatological practice
Vitamin A and its synthetic analogues are used in the treatment of numerous skin diseases. The main genomic effects of the natural form of vitamin A (retinol palmitate) are associated with its active metabolite all-trans-retinoic acid and are compensated by several restrictive mechanisms. Numerous studies have proved that retinol stimulates the proliferation of keratinocytes of the basal layer of the epidermis and endothelial cells, and also activates dermal fibroblasts to synthesize proteins of the extracellular matrix of the dermis. As a result, the thickening the epidermis, increases the mechanical strength of the skin and the hydrating ability of the dermis, angiogenesis increase. The ability of retinol to enhance the adhesion of endothelial cells and leukocytes, regulate the processes of keratinization and sebum secretion was found. Vitamin A is also a powerful antioxidant. Retinol palmitate is used as the main or auxiliary drug for the treatment of a wide range of dermatoses. The principle of application is based on clinical studies and confirmed by existing experimental data. In the treatment, the following algorithm is followed. If retinol palmitate is necessary to improve epithelialization and strengthen the epidermal barrier, medium therapeutic doses should be used. For the treatment of disorders of keratinization processes, depending on the severity of the pathological condition, medium and high therapeutic doses of the drug are used. Violation of the processes of sebum secretion and severe hyperkeratosis respond better to treatment at high therapeutic doses. It should be noted that many skins clinical manifestations mostly regress under the action of vitamin A in doses that do not lead to the appearance of signs of toxicity of the drug.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
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