阿维他地尔:一种合成血管活性肠肽在COVID-19合并严重呼吸衰竭患者中的治疗效果

D. Chakraborty, Shouvik Choudhury, S. Lahiry
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摘要

尽管有动态的药物和疫苗开发进程,以减轻COVID-19的疾病负担,但治疗选择仍然非常有限。血管活性肠肽(Vasoactive intestinal peptide, VIP)具有多种生理作用,具有特定的肺保护功能。VIP可抑制人单核细胞中的SARS-CoV-2基因复制和Calu-3细胞中的病毒复制,从而进一步减少促炎介质的产生。Aviptadil是维普的一种合成形式,是唯一一种被美国食品和药物管理局(FDA)授予“快速通道”地位的肺部治疗药物,并被允许进入II期和III期临床试验。阿维他尔与非结构蛋白(nsp) 10和nsp16的初始结合,可能抑制SARS-CoV-2 nsp10和nsp16复合物的2 ' - o -甲基转移酶活性。阿维他地尔已经被证明是治疗因败血症和其他相关肺损伤引起的严重呼吸衰竭的有效选择。该药物用于SARS-CoV-2呼吸衰竭的中期分析结果,在安全性和有效性方面产生了新的希望。最近完成的一项试验以及目前正在进行的所有试验的最终结果将在未来几天阐明这种药物在治疗COVID-19中的类别效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aviptadil: Class Effect of a Synthetic Vasoactive Intestinal Peptide as a Treatment Option in Patients with COVID-19 with Severe Respiratory Failure
Despite dynamic drug and vaccine development processes to reduce the disease burden of COVID-19, the treatment options are still very limited. Vasoactive intestinal peptide (VIP) has a diversified physiological action with specific features of lung protection-related activities. VIP inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gene replication in human monocytes and the viral replication in Calu-3 cells, thus further reducing the generation of proinflammatory mediators. Aviptadil, a synthetic form of VIP, is the only pulmonary therapeutic agent to have been granted ‘fast track’ status by the U.S. Food and Drug Administration (FDA) and to be allowed into both Phase II and III clinical trials. Initial binding of Aviptadil with non-structural protein (nsp) 10 and nsp16, which may inhibit the 2’-O-methyltransferase activity of the SARS-CoV-2 nsp10 and nsp16 complex. Aviptadil has already proved to be an effective option in the treatment of severe respiratory failures due to sepsis and other related lung injuries. Interim analysis results of this drug used in respiratory failure caused by SARS-CoV-2 has evolved a new hope in regard to safety and efficacy. The final results from a recently completed trial, as well as all currently ongoing trials, will clarify the class effect of this drug in the treatment of COVID-19 in future days.
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