基于DDS技术的疫苗研究现状与展望

Q4 Pharmacology, Toxicology and Pharmaceutics

Drug Delivery System Pub Date : 2022-11-25 DOI:10.2745/dds.37.402

Atsushi Kawai, Toshiro Hirai, Yasushi Yoshioka

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摘要

The development of DDS technology has contributed critically to The unprecedentedly rapidrequirement for vaccines against coviment -19. LNP-based mRNA vaccines represent a subset of emergingDDS technology. Despite the groundbreaking nature of these vaccines，they are yet to be perfected and as such，新技术are being developed to optimize these vaccines. This review will focus on exploringone of the modalities of recombinant protein vaccines and will introduce various findings on thevaccine efficacy using antigen modification technologies，including VLPs and Fc-fusion proteins，与adjuvant improvements.Alternate:摘要针对COVID-19疫苗以前所未有的速度普及的背景下，DDS技术的发展是必不可少的。特别是mRNA疫苗中的脂质纳米粒子(LNP)的开发，可以说是DDS技术的结集。另一方面，包括mRNA疫苗在内，目前各种各样的疫苗都面临着很多问题，世界各国都期待着能够建立更有效、更安全的疫苗开发基础技术。本文聚焦于疫苗模态之一的重组蛋白疫苗，从抗原改变技术到附加组件的改良，介绍疫苗开发基础技术的最新知识。

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Current Status and Prospects of Vaccines based on DDS Technology

The development of DDS technology has contributed critically to the unprecedentedly rapid requirement for vaccines against COVID-19. LNP-based mRNA vaccines represent a subset of emerging DDS technology. Despite the groundbreaking nature of these vaccines, they are yet to be perfected and as such, new technologies are being developed to optimize these vaccines. This review will focus on exploring one of the modalities of recombinant protein vaccines and will introduce various findings on the enhancement of vaccine efficacy using antigen modification technologies, including VLPs and Fc-fusion proteins, and adjuvant improvements.Alternate :抄録COVID-19に対してかつてない速度でワクチンが普及した背景には、DDS技術の発展が必要不可欠であった。特に、mRNAワクチンにおける脂質ナノ粒子（LNP）の開発は、まさにDDS技術の結集といえよう。一方で、mRNAワクチンを含め、現状のさまざまなワクチンは多くの課題を有しており、より効果的かつ安全なワクチン開発に資する基盤技術の確立が世界的に待望されている。本稿では、ワクチンモダリティの1つである組換えタンパク質ワクチンに焦点を絞り、抗原改変技術からアジュバントの改良に至るまで、ワクチン開発基盤技術の最新知見について紹介する。

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Drug Delivery System Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

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