蝇蝇属生物勘探潜力的系统综述(鳞翅目:蝇科)

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2023-05-02 DOI:10.1080/15569543.2023.2204348

Henrique G. Riva, A. R. Amarillo‐S

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引用次数: 0

摘要

来自有毒动物的毒素是用于防御或狩猎的蛋白质。Lonomia(鳞翅目:Saturniidae)毛虫可能是致命的，并且意外地将其鬃毛中的毒液接种到人体皮肤上会导致全身血液凝固障碍。一些综述研究了慢性中毒的病理生理;但考虑到毒液的生物开发潜力，本文重点介绍了Lonomia spp衍生物质的不同应用。按照PRISMA指南，从1996年至2019年发表的1032篇论文中选择了39篇。鉴定了九种不同用途:抗蛇毒、细胞培养、血栓治疗、伤口愈合、抗病毒和抗生素治疗、洛诺米亚种群控制、血小板粘附研究和癌症治疗。报道最多的应用(38%)涉及在细胞培养中使用lonomic组分作为细胞存活促进剂。这篇综述还指出，目前的知识差距阻碍了这些分子的实际应用。其他一些应用，包括血栓治疗、伤口愈合、抗病毒和抗生素治疗、Lonomia种群控制、血小板粘附研究和癌症治疗，由于缺乏或缺乏体内研究而受到类似知识空白的限制。最后，抗病毒治疗和血栓治疗是需要重组生产所研究的分子的两个应用。

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A systematic review of the bioprospecting potential of Lonomia spp. (Lepidoptera: Saturniidae)

Abstract Toxins from venomous animals are proteins used for their defense or to hunt. Lonomia (Lepidoptera: Saturniidae) caterpillars can be lethal, and accidental inoculation of the venom from its bristles into human skin causes systemic blood coagulation disorders. Several reviews have investigated the pathophysiology of lonomic poisoning; however, considering the potential of venoms for bioprospecting, this review focuses on the different applications of substances derived from Lonomia spp. Following PRISMA guidelines, 39 articles were selected from 1032 papers published from 1996 to 2019. Nine different applications of substances derived from Lonomia spp. were identified: lonomic antivenom, use in cell culture, thrombosis treatment, wound healing, antiviral and antibiotic treatment, Lonomia population control, platelet adhesion research and cancer treatment. The most-reported application (38%) involved using lonomic components as cell survival promoters in cell culture. This review also notes the current knowledge gaps that block the practical use of these molecules. Several additional applications, including thrombosis treatment, wound healing, antiviral and antibiotic treatment, Lonomia population control, platelet adhesion research and cancer treatment, are limited by similar knowledge gaps related to the shortage or absence of in vivo studies. Finally, antiviral treatment and thrombosis treatment are two applications that require recombinant production of the molecule studied.

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.