乳腺癌瘤周淋巴管生成

S. Gantsev, S. Kzyrgalin, K. Gantsev
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引用次数: 0

摘要

目的:评估显微镜下可辨别的癌周淋巴管生成与乳腺癌生存率之间的相关性;揭示癌症腋窝淋巴系统结构的宏观变化规律。材料和方法:我们对100名在T1-3N1-2M0期乳腺癌手术中接受超声脂肪分解治疗的妇女的腋窝组织复合体进行了形态计量学检查。通过计数淋巴管生成“点”的数量来确定实现的淋巴管的密度。单个淋巴管之间的吻合被视为一个“点”。使用Pearson参数分析确定肉眼可见的肿瘤周围淋巴管生成表达与生存率的相关性。结果:淋巴图的分析使我们能够揭示乳腺癌腋窝淋巴收集器重组的一些模式,并区分以下类型:“顺序”、“Magistral”、“均匀”、“放射状”和“网状”。根据前瞻性观察结果,观察组有16名患者在5年内死亡。根据Pearson相关分析,相关系数为0.87,决定系数为07488,p值为0000015,表明在乳腺癌中,T1-3 N1-2 M0期肿瘤周围淋巴管生成的“点数”与根治性手术治疗后的寿命之间存在统计学上显著的直接相关性。肿瘤周围淋巴管生成过程中的淋巴管是补偿保护资源状况的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peritumoral Lymphangiogenesis in Breast Carcinoma
Objective: to assess the correlation between microscopically discernible peritumoral lymphangiogenesis and breast carcinoma survival rates; to reveal the regularities of macroscopic changes in the structure of axillary lymphatic system in breast cancer. Materials and Methods: We carried out morphometric examination of axillary tissue complexes that had been taken from 100 women during surgery for breast carcinoma, stage T1-3N1-2M0 and had been treated with sonolipodistruction. The density of realized lymphatic vessels was determined by counting the number of lymphangiogenesis "points". An anastomosis between individual lymphatic vessels was taken as a "point". Correlation of macroscopically distinguishable peritumoral lymphangiogenesis expression and survival rate was determined using Pearson's parametric analysis. Results: The analysis of lymphatic maps allowed us to reveal some patterns of axillary lymphatic collector reorganization in breast carcinoma and to distinguish the following types: "Sequential", "Magistral", "Uniform", "Radial" and "Reticulate". Based on the results of prospective observation, 16 patients from the observation group died within the period of 5 years. According to the Pearson correlation analysis, the correlation coefficient was 0,87, the determination coefficient was 0,7488, the value of p = 0,000015, which indicates that in the breast carcinoma, stage T1-3 N1-2 M0 there is a statistically significant direct correlation between the number of "points" of macroscopically distinguishable peritumoral lymphangiogenesis and lifespan after a radical surgical treatment. Lymphatic vessels in the process of peritumoral lymphangiogenesis are the indicator of compensatory-protective resources condition.
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