转化性滤泡淋巴瘤的遗传学

IF 0.9 Q4 HEMATOLOGY
Hemato Pub Date : 2022-10-01 DOI:10.3390/hemato3040042
M. Alcoceba, M. García-Álvarez, J. Okosun, S. Ferrero, M. Ladetto, J. Fitzgibbon, R. García-Sanz
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引用次数: 1

摘要

组织学转化(HT)为一种更具侵袭性的疾病——主要是弥漫性大B细胞淋巴瘤——被认为是滤泡性淋巴瘤(FL)临床过程中最令人沮丧的事件之一。目前的知识还没有发现单一的HT特异性生物事件,尽管不同的研究强调了常见的基因改变,如TP53和CDKN2A/B缺失,以及MYC易位等。它们共同增加了HT的基因组复杂性和突变负担。更好地了解HT的发病机制可能有助于找到诊断生物标志物,从而识别转化高危患者,并区分FL复发患者和仍处于缓解期的患者。这也将有助于确定新的药物靶点和设计治疗转化的临床试验。在本综述中,我们对转化FL中经常发现的导致攻击性行为转变的遗传事件进行了全面综述,并将讨论HT领域目前的未决问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetics of Transformed Follicular Lymphoma
Histological transformation (HT) to a more aggressive disease–mostly diffuse large B-cell lymphoma–is considered one of the most dismal events in the clinical course of follicular lymphoma (FL). Current knowledge has not found a single biological event specific for HT, although different studies have highlighted common genetic alterations, such as TP53 and CDKN2A/B loss, and MYC translocations, among others. Together, they increase genomic complexity and mutational burden at HT. A better knowledge of HT pathogenesis would presumably help to find diagnostic biomarkers allowing the identification of patients at high-risk of transformation, as well as the discrimination from patients with FL recurrence, and those who remain in remission. This would also help to identify new drug targets and the design of clinical trials for the treatment of transformation. In the present review we provide a comprehensive overview of the genetic events frequently identified in transformed FL contributing to the switch towards aggressive behaviour, and we will discuss current open questions in the field of HT.
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来源期刊
CiteScore
1.30
自引率
0.00%
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审稿时长
11 weeks
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