连续给药万古霉素PK/PD建模药代动力学软件Mw\Pharm 3.30(DOS)和Mw\Parm++(Windows)版本的比较

Q4 Health Professions
M. Hricová, B. Koristkova, Eliška Vavreckova, I. Kacířová, H. Brozmanova, M. Grundmann
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引用次数: 0

摘要

目的:长期以来,Mw\Pharm软件套件(MEDI\WARE, Prague, Czech Republic/Groningen, Netherlands)一直被用于治疗药物监测(TDM)中的PK/PD建模。本研究的目的是在较新的Windows版本Mw\Pharm++ 1.3.5.558 (WIN)中寻找万古霉素持续给药的最佳模型。患者:20例成人患者,平均年龄66±12岁,体重85±16 kg,中位剂量1625 g/24 h反复检查万古霉素。方法:将“#vancomycin_adult_k_C2”、“#vancomycin_adult_C2”、“vancomycin_adult_C2”、“van-comycin_C1”WIN模型和“万古霉素(cont.inf.) %ahz”(DOS1)、“万古霉素成人”DOS模型预测的浓度与实测值和DOS1模型进行比较。统计学:预测误差百分比(%PE)计算为(预测-测量)/测量或(预测-DOS1)/DOS1,均方根误差,Bland-Altman偏差,皮尔逊等级相关系数(R),学生t检验。使用GraphPad Prism version 5.00 for Windows进行统计分析。结果:%PE值介于- 3.2±33.0%和- 7.4±36.7%之间,万古霉素c1模型为- 20.8±39.4%,是唯一的单室模型。万古霉素成药组疗效最好。在WIN模型中,“#vancomy-cin_adult_k_C2”模型产生了最低的%PE、RMSE和Bland-Altman偏差,但其相关性(Pearson’s R)不太紧密。“vancomycin_adult_C2”的RMSE相同,而%PE和Bland-Altman偏差相似,与“#vancomycin_adult_k_C2”相比,相关性略好。两种DOS模型的%PE值为4.1±13.9% (NS);“万古霉素成人组”的疗效略好于DOS1组。结论:“vancomycin_adult_C2”和“#vancomycin_adult_k_C2”在WIN模型间的疗效最好。两种DOS模型都产生了较低的偏差,并且它们的预测具有可比性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Mw\Pharm 3.30 (DOS) and Mw\Pharm ++ (Windows) Versions of Pharmacokinetic Software for PK/PD Modelling of Vancomycin in Continuous Administration
Objective: For a long time, the Mw\Pharm software suite (MEDI\WARE, Prague, Czech Republic/Groningen, Netherlands) has been used for PK/PD modelling in therapeutic drug monitoring (TDM). The aim of this study was to find the best model in the newer Windows version of Mw\Pharm++ 1.3.5.558 (WIN) for continuous administration of vancomycin. Patients: Twenty adult patients with a mean age of 66 ± 12 years, body weight 85 ± 16 kg, and median dose 1,625 g/24 h were repeatedly examined for vancomycin. Methods: Concentrations predicted by “#vancomycin_adult_k_C2”, “#vancomycin_adult_C2”, “vancomycin_adult_C2”, “van-comycin_C1” WIN models and “vancomycin (cont.inf.) %ahz” (DOS1) and “vancomycin adult” DOS models were compared with the measured values and with the DOS1 model. Statistics: Percentage prediction error (%PE) calculated as (predicted-measured)/measured or (predicted-DOS1)/DOS1, RMSE, Bland-Altman bias, Pearson’s coefficient of rank correlation (R), Student’s t-test. Statistical analysis was performed using the GraphPad Prism version 5.00 for Windows. Results: %PE values varied between −3.2 ± 33.0% and −7.4 ± 36.7%, with the exception of “vancomycin_C1” , the only one--compartment model, where it was −20.8 ± 39.4%. The best outcomes were achieved with “vancomycin adult” . The “#vancomy-cin_adult_k_C2” model produced the lowest %PE, RMSE, and Bland-Altman bias among the WIN models, but its correlation (Pearson’s R) was less tight. RMSE was the same in “vancomycin_adult_C2” while %PE and Bland-Altman bias were similar, with slightly better correlation when compared to “#vancomycin_adult_k_C2” . The %PE value between the two DOS models was 4.1 ± 13.9% (NS); “vancomycin adult” produced slightly better outcomes than DOS1. Conclusion: “vancomycin_adult_C2” and “#vancomycin_adult_k_C2” produced the best outcomes between WIN models. Both DOS models produced lower bias and their prediction was comparable.
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来源期刊
Klinicka Farmakologie a Farmacie
Klinicka Farmakologie a Farmacie Health Professions-Pharmacy
CiteScore
0.30
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