片状鱼鳞病患者皮肤微生物组的病例对照研究

Mehak Singh, M. Pawar
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引用次数: 0

摘要

摘要简介:片状鱼鳞病是一种角化的遗传性疾病,这些患者频繁的皮肤感染可能是由于正常皮肤菌群的改变,而物理屏障的破坏起到了补充作用。材料和方法:对2015年7月1日至2016年6月31日参加皮肤科IPD/OPD的板层鱼鳞病患者和年龄/性别对照的匹配患者进行比较回顾性研究,这些患者的皮肤拭子结果呈阳性。然后根据细菌培养结果对两组进行比较。结果:研究对象出生时的平均胎龄为35.56周(范围:30-39周)。研究样本包括LI组的6名男性和3名女性,对照组的12名男性和6名女性。耐甲氧西林金黄色葡萄球菌(MRSA)仅见于LI患者,并且在LI患者中发现的革兰氏阴性杆菌、梭杆菌和念珠菌比对照组更多。拟杆菌门与厚壁菌门的比例、亲脂性白喉杆菌、痤疮丙酸杆菌、梭杆菌和微球菌在对照组中的出现率高于LI患者。结论:通过了解这些微生物群,可以减少对抗生素的过度依赖,因为这些微生物可能在特定的微环境中形成正常的共生体。此外,这些生物体可能负责通过复合遗传角质形成细胞屏障使疾病过程永久化。已知情况:在片状鱼鳞病患者中,频繁的皮肤感染并不罕见。新情况:耐甲氧西林金黄色葡萄球菌(MRSA)常见于LI患者,革兰氏阴性杆菌、梭杆菌和念珠菌在LI患者中比对照组患者更常见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Case-Control Study of Skin Microbiome in Patients with Lamellar Ichthyosis
Abstract Introduction: Lamellar ichthyosis is a genetic disorder of keratinization and the frequent skin infections in these patients may be a result of change in normal skin flora acting in addendum to breach in the physical barrier. Material and Methods: A comparative retrospective study was performed in patients with lamellar ichthyosis and age/ sex controlled matched patients attending the dermatology IPD/OPD with positive skin swab results from July 1st 2015 to June 31st 2016. The two groups were then compared in terms of bacterial culture results. Results: The mean gestational age of the study subjects at birth was 35.56 weeks (range: 30–39 weeks). The study sample consisted of 6 males and 3 females in LI group and 12 males and 6 females in the control group. Methicillin resistant Staphylococcusaureus (MRSA) was exclusively seen in LI patients, and Gram negative rods, Fusobacterium and Candida were found more in the LI patients than in the control group. The Bacteroidetes to Firmicutes ratio, lipophilic diphtheroids, Propionibacterium acnes, Fusobacterium and Micrococci were present more in the control group than in the LI patients. Conclusion: By knowing this microbiota, undue reliance on antibiotics can be reduced as these microorganisms may form normal commensals for the given micro environment. Furthermore, these organisms may be responsible for perpetuating the disease process by compounding the genetic keratinocyte barrier. What is known: Frequent skin infections are not uncommon in patients of lamellar ichthyosis. What is new: Methicillin resistant Staphylococcus aureus (MRSA) are commonly present in LI patients, and Gram negative rods, Fusobacterium and Candida are commoner in the LI patients than in the control group of patients.
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期刊介绍: Serbian Journal of Dermatology and Venereology is a journal of the Serbian Association of Dermatologists and Venereologists. The journal is published in English, quarterly and intended to provide rapid publication of papers in the field of dermatology and venereology. Manuscripts are welcome from all countries in the following categories: editorials, original studies, review articles, professional articles, case reports, and history of medicine.
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