红细胞膜性质的变化:代谢综合征成分的作用

Q4 Biochemistry, Genetics and Molecular Biology
Yuliya Birulina, I. Petrova, V. V. Ivanov, E. Buyko, R. R. Shaibekova, A. Grigoreva, I. Kovalev, A. Nosarev, S. Gusakova
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引用次数: 0

摘要

代谢综合征(MetS)是一组代谢、激素和血液动力学疾病,导致红细胞结构和功能状态的改变,并导致其阳离子运输功能失调,其中Ca2+依赖性钾通道(KCa通道)起重要作用。采用雄性Wistar大鼠建立MetS模型,分为对照组和实验组。对照组大鼠饲喂标准鼠粮。实验组大鼠喂食高脂高碳水化合物(HFHC) 12周。所获得的数据表明HFHC饮食导致肥胖、高血压、高血糖、糖耐量受损和血脂异常。MetS大鼠红细胞中谷胱甘肽(GSH)水平降低,丙二醛(MDA)水平升高。结果表明,met大鼠红细胞膜电位的幅值随作用剂的不同而变化:用钙离子载体A23187刺激时,其幅值降低;用抗坏血酸-苯那嗪甲硫代硫酸盐氧化还原系统时,其幅值较对照组增加。所获得的数据表明,HFHC饮食导致红细胞膜的物理和化学性质的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in Red Blood Cell Membrane Properties: The Role of Metabolic Syndrome Components
Metabolic syndrome (MetS) is a cluster of metabolic, hormonal and hemodynamic disorders that contribute to a change in the structural and functional status of erythrocytes and contribute to dysregulation of their cation transport function, where Ca2+ -dependent potassium channels (KCa channels) play an important role. A MetS model was performed using male Wistar rats, which were divided into control and experimental groups. Rats in the control group were fed standard rat chow. Rats in the experimental group were exposed to a high-fat and high-carbohydrate (HFHC) diet for 12 weeks. The data obtained indicate that the HFHC diet led to obesity, high blood pressure, hyperglycemia, impaired glucose tolerance, and dyslipidemia. The level of glutathione (GSH) decreased in the erythrocytes of rats suffering from MetS, but the level of malondialdehyde (MDA) increased. It was shown that the amplitude of the membrane potential of erythrocytes of rats with MetS changed depending on the acting agent: when stimulated with calcium ionophore A23187 it decreased, when the redox system ascorbat –phenazine methosulfate was used, it increased compared to the control group. The data obtained indicate that a HFHC diet leads to changes in the physical and chemical properties of the erythrocyte membrane.
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来源期刊
International Journal of Biology and Biomedical Engineering
International Journal of Biology and Biomedical Engineering Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
自引率
0.00%
发文量
42
期刊介绍: Topics: Molecular Dynamics, Biochemistry, Biophysics, Quantum Chemistry, Molecular Biology, Cell Biology, Immunology, Neurophysiology, Genetics, Population Dynamics, Dynamics of Diseases, Bioecology, Epidemiology, Social Dynamics, PhotoBiology, PhotoChemistry, Plant Biology, Microbiology, Immunology, Bioinformatics, Signal Transduction, Environmental Systems, Psychological and Cognitive Systems, Pattern Formation, Evolution, Game Theory and Adaptive Dynamics, Bioengineering, Biotechnolgies, Medical Imaging, Medical Signal Processing, Feedback Control in Biology and Chemistry, Fluid Mechanics and Applications in Biomedicine, Space Medicine and Biology, Nuclear Biology and Medicine.
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