固相肽合成LfcinB短肽类似物作为全球微生物耐药的替代品

Dimana Dimitrova Georgieva
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摘要

摘要抗生素是治疗病原菌感染的主要药物。它们的频繁和长期使用导致了抗性微生物的发展和传播。根据世界卫生组织的说法,全球对传统抗菌治疗的耐药性正在令人担忧地增加。这反过来又对公众健康构成严重风险,需要寻找传统病原体治疗的替代方案。抗菌肽(AMPs)在这方面引起了极大的兴趣。它们在所有生物体中自然产生,是抵御真菌、病毒和细菌的第一道防线。已经证明具有抗菌作用的AMP的一个例子是乳铁蛋白。它们是阳离子两亲肽,已在人类(LfcinH)和其他哺乳动物(牛(Lfcin B)、小鼠(Lfcin-M)和山羊(Lfcin.C)中发现。其中最强大的抗菌作用是LfcinB。使用SPPS方法,获得了短肽分子,即LfcinB的类似物,与天然肽相比,其显示出更强的抗菌效果。近年来,乳铁蛋白已成为许多科学研究的主题,并代表了开发对抗抗菌药物耐药性的新疗法的潜在替代品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short peptide analogs of LfcinB synthesized by Solid Phase Peptide Synthesis as an alternative to global microbial resistance
Abstract Antibiotics are the main therapy in the treatment of infections caused by pathogenic bacteria. Their frequent and prolonged use leads to the development and spread of resistant microorganisms. According to the WHO, there is a worrying increase in global resistance to conventional antimicrobial therapy. This in turn poses a serious risk to public health and requires the search for an alternative to traditional pathogen therapy. Antimicrobial peptides (AMPs) are of great interest in this regard. They are produced naturally in all living organisms and are the first line of defense against fungi, viruses and bacteria. An example ofAMP with proven antimicrobial action are lactoferricins. They are cationic amphipathic peptides and have been found in both humans (LfcinH) and other mammals (cattle (LfcinB), mice (LfcinM) and goats (LfcinC). The most powerful antibacterial effect among them shows LfcinB. Using SPPS methods, short peptide molecules were obtained, analogs of LfcinB, which show a stronger antibacterial effect compared to the native peptide. In recent years, lactoferricins have been the subject of a number of scientific studies and represent a potential alternative for the development of new therapies to combat antimicrobial drug resistance.
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