四阶导数光谱法同时测定氨氯地平和赖诺普利二水合物

A. Nejres, Moath Abdallah Najem
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引用次数: 0

摘要

基于药物中化合物的零交叉点测定技术,采用四阶导数光谱法,建立了一种快速简便的同时测定联合用药中赖诺普利和氨氯地平的新方法。二水赖诺普利和氨氯地平在溶剂介质中的波长值分别为(203、207和231 nm)和(215、254和277 nm),平均值在2.0至45.0µg/mL和2.0至35.0µg/mL。二水赖诺普利具有摩尔吸光率区域(9227.76-11700.28 L/mol.cm,203 nm)、(15320.74-20795.59 L/mol.cm-207 nm)和(2207.60-3311.40 L/mol-cm,231 nm),而氨氯地平(5886.72-10914.96 L/mol.cm.215 nm)、。二水赖诺普利在药物剂型范围内的回收率为95.13-102.60%,氨氯地平为95.14-102.80%。相对误差结果表明,干扰不影响这些化合物的估算方法。所提出的方法已成功应用于药物剂型的估计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Simultaneous determination of amlodipine and lisinopril dihydrate using fourth derivative spectroscopy
A new fast and simple selective method for the simultaneous determination of lisinopril dihydrate and amlodipine in combined drugs was developed using the fourth derivative spectrum method, based on the zero-crossing-point technique for the determination of compounds in drugs. The wavelength values for lisinopril dihydrate and amlodipine in solvent medium were found to be (203, 207, and 231 nm) and (215, 254, and 277 nm), respectively, with the average obeying Beer’s law in the range of lisinopril dihydrate 2.0 to 45.0 µg/mL and amlodipine 2.0 to 35.0 µg/mL. Lisinopril dihydrate has molar absorptivity regions (9227.76-11700.28 L/mol.cm, 203 nm), (15320.74-20795.59 L/mol.cm, 207 nm), and (2207.60-3311.40 L/mol.cm, 231 nm), while amlodipine (5886.72-10914.96 L/mol.cm, 215 nm), (5518.8-6418.16 L/mol.cm, 254 nm) and (1676.08-1921.36 L/mol.cm, 277 nm). The recovery rate of lisinopril dihydrate in the pharmaceutical dosage forms range was 95.13 to 102.60% and amlodipine 95.14 to 102.80%. The results of the relative error showed that the interferences did not affect the method of estimating these compounds. The proposed method has been successfully applied to estimate pharmaceutical dosage forms.
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