传统壁花油的表征及色谱指纹图谱分析

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
G. Mosleh, A. Azadi, A. Mohagheghzadeh
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引用次数: 0

摘要

背景与目的:壁花油是由富含卡酚类化合物的草本植物车轴草(Erysimum cheiri(L.)Crantz)的花朵制成的。壁花油传统上用于镇痛、抗炎、护发和伤口愈合。本文采用波斯医药文献中引用的方法制备了壁花油。方法:将250克干花在5000克蒸馏水中浸泡20小时,然后煮沸2小时,直到蒸发掉一半的水。将获得的汤剂过滤并在2500g芝麻油中煮沸,直到所有含水部分蒸发。进行了质量控制测试。结果:酸、过氧化物、碘和皂化值分别为0.72±0.02(油酸%)、7.16±0.10(meq/kg油)、104.73±0.71(g I2/100 g油)和242.85±0.29(mg KOH/g油)。HPTLC分析显示,壁花油、煎剂、浸液和花样品中存在卡酚类化合物。GC-FID结果表明,亚油酸(42.91%)、油酸(41.22%)和棕榈酸(9.76%)是壁花油的主要脂肪酸。此外,GC-MS研究鉴定了11种挥发性化合物,其中百里酚(28.13%)、香芹酚(21.63%)和十二烷(11.50%)为主要成分。结论:百里香酚和香芹酚可用于壁花油的评价和含量测定。另一方面,在临床给药时,应考虑壁花油中是否存在卡酚类化合物以及由此产生的可能的心脏活动。本文建议进一步进行体外和体内研究以及临床试验,以评估壁花油的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization and Chromatographic Fingerprint Analysis of Traditional Wallflower Oil
Background and objective: Wallflower oil is made from the flowers of Erysimum cheiri (L.) Crantz which is a herb rich in cardenolide compounds. Wallflower oil was traditionally indicated for analgesic, anti-inflammatory, hair tonic, and wound healing purposes. In this paper, wallflower oil was prepared based on the method cited in Persian medicine resources. Methods: To prepare the oil, 250 g dried flower was soaked in 5000 g distilled water for 20 h. Then, it was boiled for 2 h till half of the water volume evaporated. The obtained decoction was filtered and boiled in 2500 g sesame oil until all the aqueous part evaporated. The quality control tests were performed. Results: Acid, peroxide, iodine, and saponification values were determined as 0.72±0.02 (oleic acid%), 7.16±0.10 (meq/kg oil), 104.73±0.71 (g of I2/100 g oil), and 242.85±0.29 (mg KOH/g oil), respectively. HPTLC analysis revealed the presence of cardenolide compounds in wallflower oil, decoction, maceration, and flower samples. GC-FID results recognized linoleic acid (42.91%), oleic acid (41.22%), and palmitic acid (9.76%) as major fatty acids of wallflower oil. In addition, GC-MS study identified 11 volatile compounds among which, thymol (28.13%), carvacrol (21.63%), and dodecane (11.50%) were recognized as the main components. Conclusion: Thymol and carvacrol could be used for evaluation and determination of wallflower oil. On the other hand, presence of cardenolides in wallflower oil and consequent probable cardiac actions should be considered during clinical administrations. This paper recommends further in vitro and in vivo studies as well as clinical trials to evaluate the safety and efficacy of wallflower oil.
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来源期刊
Research Journal of Pharmacognosy
Research Journal of Pharmacognosy PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
20.00%
发文量
0
审稿时长
8 weeks
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