帕金森病的静息功能连通性和轻度认知障碍。脑电图研究

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2019-05-01 DOI:10.2217/FNL-2018-0048

Jairo Alexander Carmona Arroyave, Carlos Andrés Tobón Quintero, Jasmín Jimena Suárez Revelo, J. F. Gómez, Yamile Bocanegra García, Leonardo Moreno Gómez, David Antonio Pineda Salazar

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引用次数: 11

摘要

目的：帕金森病（PD）以认知缺陷为特征。目前尚不清楚与患者认知特征相关的脑电图（EEG）连接。我们的目的是评估非痴呆性帕金森病患者静息脑电图的连接性。方法：使用静息脑电图的局部、半球内和半球间连接性的一致性来评估患有和不患有轻度认知障碍（MCI）的帕金森病受试者。结果：与对照组相比，没有MCI（PD-nMCI）的PD受试者在alpha2中的脑内和脑间连贯性较低。与PD nMCI相比，具有MCI的PD（PD-MCI）在α2和β1中分别显示出更高的大脑半球内和后半球间一致性。与PD-nMCI相比，PD-MCI在β频率上表现出较低的额叶相干性。结论：脑电相干测量显示有无MCI的帕金森病患者的皮层活动不同。

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Resting functional connectivity and mild cognitive impairment in Parkinson’s disease. An electroencephalogram study

Objective: Parkinson’s disease (PD) is characterized by cognitive deficits. There is not clarity about electroencephalogram (EEG) connectivity related to the cognitive profile of patients. Our objective was to evaluate connectivity over resting EEG in nondemented PD. Methods: PD subjects with and without mild cognitive impairment (MCI) were assessed using coherence from resting EEG for local, intra and interhemispheric connectivity. Results: PD subjects without MCI (PD-nMCI) had lower intra and interhemispheric coherence in alpha2 compared with controls. PD with MCI (PD-MCI) showed higher intra and posterior interhemispheric coherence in alpha2 and beta1, respectively, in comparison to PD-nMCI. PD-MCI presented lower frontal coherence in beta frequencies compared with PD-nMCI. Conclusion: EEG coherence measures indicate distinct cortical activity in PD with and without MCI.

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.