动物产生的抗菌肽和化学物质对烟曲霉的影响

Al-Baraa Akram, Glen J. P. McCann
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引用次数: 0

摘要

除了限制在食品中使用抗生素作为促生长物质外,细菌、真菌和酵母等耐多药病原体的问题也引起了人们的注意,即寻找替代来源,而不是寻找具有抗菌活性的天然产品等传统抗生素。许多兴趣和研究都集中在使用从动物分泌物和一些昆虫毒液中提取的天然抗菌肽和化学物质上,因为如果将它们与它们的混合物联合使用,它们对病原体表现出较低的耐药性和较高的协同作用。在本文中,使用光密度分析技术显示了从长颈鹿中提取的一些抗菌化学物质除了对烟曲霉物种的活性外,还将确定它们的最小抑制浓度(MIC),以及使用Gene5等程序测量抑制生物功能的效力的IC50,以及测试动物分泌物中提供的一些化学物质的抗菌活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Antimicrobial Peptides and Chemicals Produced by Animals on Aspergillus fumigatus
The problem of multidrug-resistant pathogens as bacteria, fungi and yeast in addition to the restriction of using antibiotics as growth promoting substances in food has attracted the attention to looking for alternative sources instead of conventional antibiotics like natural products which have antimicrobial activity. Much interests and researches have been focused on using natural antimicrobial peptides and chemicals extracted from animal secretions and some insect’s venoms as they exhibit antimicrobial activity against pathogens with lower resistance and higher synergistic effects if they were given in combination with blends of them. In this paper, some antimicrobial chemicals extracted from giraffes are shown in addition to their activity against Aspergillus fumigatus species using optical density analysis technique then their Minimum Inhibitory Concentrations (MIC) will be determined as well as ICs 50 to measure the potency to inhibit a biological function using programmes like Gene5, graph pad prism as well as testing antimicrobial activity of some chemicals which are provided in animal secretions.
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