使用以替诺福韦为基础的暴露前预防推进艾滋病毒预防

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Antiviral Therapy Pub Date : 2022-02-01 DOI:10.1177/13596535211067589

S. A. Abdool Karim, C. Baxter, Q. Abdool Karim

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引用次数: 0

摘要

基于替诺福韦的暴露前预防（PrEP）彻底改变了全球艾滋病毒预防格局。在2010年的概念验证试验证明替诺福韦（TFV）可以预防艾滋病毒的性传播之前，预防选择主要局限于行为改变、避孕套和包皮环切。随后的几项研究评估了口服富马酸替诺福韦二酯（TDF）或TDF/恩曲他滨（FTC）组合作为预防艾滋病毒的PrEP，为监管部门批准并纳入国家和国际指南提供了证据。截至2021年，已有150万人开始口服基于替诺福韦的PrEP，这有助于降低一些地区的艾滋病毒发病率。在这里，我们反思了口服替诺福韦PrEP如何成为全球HIV联合预防计划的重要组成部分。

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Advancing HIV prevention using tenofovir-based pre-exposure prophylaxis

Tenofovir-based pre-exposure prophylaxis (PrEP) revolutionized the global HIV prevention landscape. Prior to the proof-of concept trial in 2010, which demonstrated that tenofovir (TFV) could prevent sexual transmission of HIV, prevention options were largely limited to behavior change, condoms, and circumcision. Several subsequent studies evaluating oral tenofovir disoproxil fumarate (TDF) or the TDF/emtricitabine (FTC) combination as PrEP for HIV prevention provided evidence for regulatory approval and inclusion in national and international guidelines. By 2021, 1.5 million people had initiated oral tenofovir-based PrEP, contributing to declines in HIV incidence in some regions. Here we reflect on how oral tenofovir-based PrEP became an important component of combination HIV prevention programs across the globe.

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来源期刊

Antiviral Therapy 医学-病毒学

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.