NOD小鼠Sjögren综合征自发性模型的建立

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Protocols in Pharmacology Pub Date : 2019-08-05 DOI:10.1002/cpph.65

Monika D. Scuron, Brittany Fay, Julian Oliver, Paul Smith

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引用次数: 15

摘要

非肥胖糖尿病(NOD)小鼠模型是研究人类原发性Sjögren综合征(SS)最广泛描述和验证的方法，代表了转化研究的有用模型。然而，NOD小鼠的全身性疾病表现对居住环境敏感，因为应激调节免疫系统，因此有必要确认读数是稳健的、可重复的，并且对已知的临床治疗敏感。该协议描述了SS自发NOD模型的建立，并强调了模型验证的必要性，以确保住房环境的兼容性。©2019 by John Wiley &儿子,Inc。

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Spontaneous Model of Sjögren's Syndrome in NOD Mice

The non-obese diabetic (NOD) mouse model is the most widely described and validated method for investigating human primary Sjögren's syndrome (SS) and represents a useful model for translational studies. However, the systemic disease manifestation in NOD mice is sensitive to the housing environment, as stress modulates the immune system, so it is essential to confirm that readouts are robust, reproducible, and sensitive to known clinical treatments. This protocol describes the establishment of the spontaneous NOD model of SS and underscores the necessity of model validation to ensure that the housing environment is compatible. © 2019 by John Wiley & Sons, Inc.

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Current Protocols in Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

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