角膜胶原交联(CXL)与CXL联合飞秒激光辅助角膜环段植入术治疗圆锥角膜

IF 0.1 Q4 OPHTHALMOLOGY
Seham Ahmed, Khalid Rashad, A. Elmassry, E. Osman
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引用次数: 0

摘要

背景角膜交联术已被证明是治疗和稳定圆锥角膜进展的有效方法,但患者仍需要早期视力康复。目的比较CXL和层内角膜环段联合植入术与单独交联植入术在圆锥角膜患者视力、屈光度和某些角膜地形参数方面的结果。设计这是一项前瞻性、比较性和介入性研究。患者和方法本研究对44例(60眼)18~36岁的圆锥角膜患者进行了研究。30只眼睛接受CXL单独手术,30只眼睛进行联合手术。对所有患者在术前和术后3、6个月和1年进行测量,包括独立视力、最佳矫正视力、屈光度和地形结果。结果在整个研究期间,这两种手术在治疗和稳定圆锥角膜进展方面都是安全有效的。此外,与CXL组相比,联合组在以下方面表现出额外的改善:3个月时的UDVA(P=0.0028),1年时的最佳矫正视力(P=0.011),所有随访的屈光性和角膜测量性散光,以及3个月和6个月随访的角膜非球面性(P=0.013)和0.0221)。在整个研究期间,两组均未观察到严重的术中或术后并发症。结论联合手术除了能起到稳定角膜的作用外,还能早期改善视力和屈光结果,是安全有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Corneal collagen cross-linking (CXL) versus combined CXL and femtosecond laser-assisted intracorneal ring segment implantation for the treatment of keratoconus
Background The corneal cross-linking procedure has been proven to be an effective method to treat and stabilize keratoconus progression, but early vision rehabilitation is still needed in patients. Aim The aim was to compare the results of the combined CXL and intrastromal corneal ring segment implantation procedure to that of the cross-linking-alone procedure in terms of visual acuity, refraction, and some corneal topographic parameters in keratoconic patients. Design This was a prospective, comparative, and interventional study. Patients and methods This study was carried out on 44 keratoconic patients (60 eyes) of both sexes who ranged from 18 to 36 years. Thirty eyes were subjected to the CXL-alone procedure and 30 eyes were subjected to the combined procedure. Measurements were performed in all patients preoperatively and at 3, 6 months, and 1 year postoperatively including unaided visual acuity, best-corrected visual acuity, refractive, and topographic outcomes. Results Through the entire study period, both procedures were safe and effective in treating and stabilizing keratoconus progression. Furthermore, the combined group showed additional improvements over the CXL group for the following: UDVA at 3 months (P=0.0028), best-corrected visual acuity at 1 year (P=0.011), refractive and keratometric astigmatism at all follow-up visits and corneal asphericity at 3 months (P=0.013) and 6 months (P=0.0221) of follow-up. No severe intraoperative or postoperative complications were observed during the entire study period in either group. Conclusions The combined procedure is safe and effective for earlier improvement of visual and refractive outcomes in addition to the corneal stabilizing effect.
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