GLIS3多态性与糖尿病易感性:一项系统综述和荟萃分析

IF 0.8 Q4 GENETICS & HEREDITY

Meta Gene Pub Date : 2021-09-01 DOI:10.1016/j.mgene.2021.100898

Guilherme Coutinho Kullmann Duarte , Tais Silveira Assmann , Bianca Marmontel de Souza , Daisy Crispim

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引用次数: 2

摘要

转录因子glis -similar 3 (GLIS3)在胰腺β细胞的发育、存活和增殖以及胰岛素基因表达调控中具有重要作用。因此，全基因组关联研究表明，GLIS3基因可增加1型和2型糖尿病(DM)的风险。然而，个体GLIS3多态性与糖尿病的关联数据仍然没有定论。因此，本系统综述和荟萃分析旨在仔细研究GLIS3多态性与糖尿病之间的潜在关联。我们在EMBASE和PubMed资源中进行了文献检索，以找到所有分析GLIS3多态性与糖尿病易感性的研究。根据入选标准，本系统综述纳入了25项研究。其中12项具有完整的可用数据，允许进行荟萃分析(T1DM: 3项rs7020673多态性研究和3项rs10758593多态性研究;T2DM: rs7034200多态性6例，rs7041847多态性3例。rs7020673和rs10758593多态性与T1DM无关。在T2DM研究中，rs7041847A和rs7034200C等位基因与T2DM风险相关(OR = 1.08, 95% CI 1.00-1.16和OR = 1.17, 95% CI 1.09-1.26);考虑等位基因对比模型)。总之，GLIS3 rs7034200和rs7041847多态性似乎增加了2型糖尿病的风险。GLIS3多态性是否与糖尿病相关还需要进一步的研究来证实。

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Polymorphisms in GLIS3 and susceptibility to diabetes mellitus: A systematic review and meta-analysis

The transcription factor Gli-similar 3 (GLIS3) has an important role in the development, survival and proliferation of pancreatic beta-cells and insulin gene expression regulation. Accordingly, genome-wide association studies have shown GLIS3 gene confers risk to both type 1 and type 2 diabetes mellitus (DM). However, data on the association of individual GLIS3 polymorphisms with DM are still inconclusive. Thus, this systematic review and meta-analysis was aimed to scrutinize the potential association between GLIS3 polymorphisms and DM. A literature search was carried out in EMBASE and PubMed resources to find all studies that analyzed GLIS3 polymorphisms regarding susceptibility to DM. Following the eligibility criteria, 25 studies were included in this systematic review. Twelve of them had complete data available, allowing meta-analyses (T1DM: 3 studies with rs7020673 polymorphism and 3 with rs10758593; T2DM: 6 with rs7034200 polymorphism and 3 with rs7041847). The rs7020673 and rs10758593 polymorphisms were not associated with T1DM. Regarding T2DM studies, the rs7041847A and the rs7034200C alleles were associated with risk for T2DM (OR = 1.08, 95% CI 1.00–1.16 and OR = 1.17, 95% CI 1.09–1.26; considering the allele contrast model). In conclusion, GLIS3 rs7034200 and rs7041847 polymorphisms seem to confer risk for T2DM. Additional studies are needed to confirm whether GLIS3 polymorphisms are associated with DM.

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.