吲哚衍生物SS-68在增加心律控制频率范围(窦房结反射刺激)中的作用

Q3 Pharmacology, Toxicology and Pharmaceutics
P. Galenko-Yaroshevsky, A. Nechepurenko, T. Pokrovskaya, Nikolai L. Shimonovsky, A. Dukhanin, K. F. Suzdalev, P.D. Maslova, Natalia M. Makhnova, Vadim V. Shneivais, V. Abushkevich, A. Zelenskaya, Valeria V. Seletskaya, Saida K. Ahedzhak-Naguse, K. Korotkov
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引用次数: 0

摘要

引言:心脏起搏适用于病态窦房结综合征。它是通过植入心脏的电极使用起搏器进行的。这种技术有几个缺点。正在寻找替代心脏起搏方法。其中之一是通过刺激耳屏来控制心律。目的:对窦房结进行反射刺激,研究SS-68物质对窦房结反射刺激的影响,并记录凌空抽射频率和心脏收缩的同步范围。在以50µg/kg的剂量静脉注射SS-68物质(2-苯基-1-(3-吡咯烷-1-环丙基)-1H-吲哚盐酸盐)后,再次记录该范围。在其他在高频电磁场中对青蛙进行的实验中,可以观察到与心律相关的延髓区域的兴奋过程。在该区域表面施加SS-68(50μM)后,记录其激发过程。结果与讨论:刺激家兔耳廓反射区可使凌空抽射频率与心率同步,范围为每分钟173.5±2.0至214.0±1.8。SS-68将该范围从168.2±1.9每分钟扩展到219.4±1.5每分钟。在青蛙的延髓中,一个与心律同步的区域在高频电磁场中发光。SS-68使发光面积增加131.0%。结论:SS-68物质通过激活窦房结反射刺激来增加心律控制的频率范围。SS-68的主要应用点是延髓。辉光在高频电磁场中反映了神经元兴奋的过程。在SS-68的影响下,辉光区的增加表明神经元同步兴奋,这导致窦房结对中央心律生成的同化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)
Introduction: Cardiac pacing is indicated for sick sinus syndrome. It is performed with a pacemaker via electrodes implanted in the heart. This technique has several disadvantages. The search for alternative methods of cardiac pacing is underway. One of them is control of heart rhythm through stimulation of the tragus. Objective: To perform the reflex stimulation of the sinoatrial node and to study the influence of the SS-68 substance on it. Materials and methods: Two electrodes were fixed in the reflexogenic zone of rabbits’ auricles, volleys of electrical impulses from an electrical stimulator were applied to the electrodes, and the synchronization range of volley frequency and cardiac contractions was recorded. This range was re-recorded again after injecting the SS-68 substance (2-phenyl-1-(3-pyrrolidine-1-cyclopropyl)-1H-indole hydrochloride) intravenously at a dose of 50 µg/kg. In other experiments on frogs in a high-frequency electromagnetic field, the process of excitation of the area of the medulla oblongata associated with the heart rhythm was visualized. After the application of SS-68 (50 μM) to the surface of this zone, the process of its excitation was recorded. Results and discussion: Stimulation of the auricular reflexogenic zone of rabbits produced a synchronization of volley frequency and heart rate in the range from 173.5 ± 2.0 to 214.0 ± 1.8 per minute. SS-68 extended this range from 168.2 ± 1.9 to 219.4 ± 1.5 per minute. In the frog’s medulla oblongata, an area synchronous to the heart rhythm glowed in the high-frequency electromagnetic field. SS-68 increased the area of glow by 131.0%. Conclusion: The substance SS-68 increases the frequency range of heart rhythm control by activating reflex stimulation of the sinoatrial node. The main point of application of SS-68 is the medulla oblongata. Glow in the high-frequency electromagnetic field reflects the process of neuron excitation. The increase in the glow zone under the influence of SS-68 indicates synchronously excited neurons, which leads to the assimilation of the central heart rhythm generation by the sinoatrial node.
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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