银纳米粒子与银钴纳米粒子对成年雄性大鼠功能及肝组织变化影响的比较

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
Z. Parang, M. Parsaeian, D. Moghadamnia
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引用次数: 1

摘要

目的:比较银纳米粒子和银钴纳米粒子对成年雄性大鼠肝功能和肝脏组织变化的影响。材料与方法:选取49只体重约180-220克的成年雄性Wistar大鼠,随机分为7组,每组7只,包括1个对照组和6个实验组。实验1组和2组分别腹腔注射合成银纳米颗粒25和100 mg/kg,持续75秒,持续14 d。实验3组给予300秒合成的银纳米颗粒,以25 mg/kg的剂量腹腔注射,连续14天。实验组4和实验组5接受银钴纳米颗粒治疗,其中银纳米颗粒在75秒内合成,分别以25和100 mg/kg的剂量腹腔注射,持续14天。最后,实验6组小鼠腹腔注射25 mg/kg剂量的钴银纳米粒子14天,合成银纳米粒子300秒。实验结束后,测定血清中肝酶、白蛋白和总蛋白水平,并观察组织变化。结果:实验1、3组患者血清AST、总蛋白、白蛋白水平均较对照组显著升高。同样,实验组3的平均血清ALT和ALP水平也较对照组显著升高。各试验组肝脏重量平均值均显著高于对照组(P<0.05)。此外,在银纳米颗粒受体中观察到肝组织坏死。然而,在接受银钴纳米颗粒治疗的组中未观察到肝坏死。结论:纳米银可提高大鼠血清肝酶水平,增加肝组织坏死。然而,银钴纳米颗粒并没有改变肝酶和肝组织的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the effects of silver nanoparticles and silver cobalt nanoparticles on function tests and liver tissue changes in adult male rats
Objective(s): This study aimed to compare impacts of silver nanoparticles and silver cobalt nanoparticles on the hepatic function tests and changes in liver tissues in adult male rats.Materials and Methods: This study was conducted on 49 adult male Wistar rats, each weighing approximately 180-220 gr. The rats were randomly assigned to seven groups of seven including one control group and six experimental groups. The experimental groups 1 and 2 respectively received 25 and 100 mg/kg of silver nanoparticles synthesized for 75 sec intraperitoneally for 14 days. Experimental group 3 received silver nanoparticles that were synthesized at 300 sec which were administered intraperitoneally in a 25 mg/kg dose for 14 days. The experimental groups 4 and 5 received silver cobalt nanoparticles, whereby silver nanoparticles were synthesized at 75 sec and were administered intraperitoneally in a 25 and 100 mg/kg dose for 14 days, respectively. Finally, experimental group 6 received a 25 mg/kg dose of silver cobalt nanoparticles, intraperitoneally for 14 days, with the silver nanoparticles synthesized for 300 sec. At the end of this period, the serum levels of hepatic enzymes, albumin, and total protein were measured and tissue changes were evaluated in this study.Results: The mean serum levels of AST, total protein, and albumin in the experimental groups 1 and 3 increased significantly compared to the control group. Similarly, the mean serum levels of ALT and ALP in the experimental group 3 showed a significant increase in comparison with the control group. The mean of liver weight in all experimental groups was significantly higher than the control group(P<0.05). Furthermore, the necrosis of the liver tissue was observed in the recipients of silver nanoparticles. However, liver necrosis was not observed in the groups receiving silver cobalt nanoparticles.Conclusion: The use of silver nanoparticles can boost the serum levels of hepatic enzymes and increase liver tissue necrosis, as well. However, the silver cobalt nanoparticles did not change the levels of hepatic enzymes and liver tissue.
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
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审稿时长
12 weeks
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