围手术期预防性静脉滴注抗生素在基于植入物的乳房重建中的作用:一项回顾性配对队列研究

IF 1.3 Q3 SURGERY
Archives of Plastic Surgery-APS Pub Date : 2024-02-07 eCollection Date: 2024-01-01 DOI:10.1055/a-2161-7521
Seok Kyung In, Seok Won Park, Yujin Myung
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引用次数: 0

摘要

背景在乳房重建方法中,基于植入物的乳房重建已成为主流。然而,假体周围感染仍是一个尚未解决的问题。尽管已发表的文章表明,有限使用抗生素足以降低感染率,但外科医生仍然倾向于延长抗生素的使用时间。我们研究的目的是验证在基于植入物的乳房重建后,抗生素使用的适当持续时间以降低感染率。方法回顾性分析235例(274个植入物用于重建)采用脱细胞真皮基质包裹技术进行体外直接植入前乳房重建的患者的病历。分析了术后使用预防性抗生素直至引流管清除的患者和围手术期仅使用24小时预防性抗生素的患者的感染率。结果在274个植入物中,98个植入物的感染率为3.06%(3个植入物),176个植入物在术后24小时内接种预防性抗生素,感染率为4.49%(8个种植物)。临床诊断为术后感染的患者共11例,其中8例经抗生素治疗后痊愈,3例植入物摘除并自体皮瓣置换。术后抗生素预防时间对感染风险无统计学意义(P=0.549)。结论术后预防性抗生素使用时间与感染风险无关。需要对大量患者进行进一步研究、随机对照研究、抗生素途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Perioperative Prophylactic Intravenous Antibiotic Use in Immediate Implant-Based Breast Reconstruction: A Retrospective Matched Cohort Study.

Background  Among breast reconstruction methods, implant-based breast reconstruction has become the mainstream. However, periprosthetic infection is still an unresolved problem. Although published articles have revealed that limited use of antibiotics is sufficient to reduce infection rates, the number of surgeons still preferring elongated usage of antibiotics is not less. The aim of our study is to validate the appropriate duration of antibiotic use to reduce infection rate after implant-based breast reconstruction. Methods  A retrospective study reviewed medical record of 235 patients (274 implants for reconstruction) who underwent prepectoral direct to implant breast reconstruction using acellular dermal matrix wrapping technique. Infection rates were analyzed for the patients administered postoperative prophylactic antibiotics until drain removal and those who received only perioperative prophylactic antibiotics for 24 hours. Results  Of the 274 implants, 98 who were administered prophylactic antibiotics until drain removal had an infection rate of 3.06% (three implants) and 176 who received prophylactic antibiotics no longer than 24 hours postoperatively had an infection rate of 4.49% (eight implants). A total of 11 patients diagnosed with postoperative infection clinically, 8 were salvaged by antibiotic treatment, and 3 had implant removal and replacement with autologous flap. Postoperative antibiotic prophylaxis duration had no statistically significant effects in the risk of infection ( p  = 0.549). Conclusion  The duration of prophylactic antibiotics after surgery was not related to infection risk. Further study with a large number of patients, randomized control study, and route of antibiotics is needed.

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来源期刊
CiteScore
2.10
自引率
6.70%
发文量
131
审稿时长
10 weeks
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