血管紧张素转换酶基因多态性可能是COVID-19临床结局的危险因素

Q3 Pharmacology, Toxicology and Pharmaceutics

Current Trends in Biotechnology and Pharmacy Pub Date : 2020-04-01 DOI:10.5530/ctbp.2020.2.24

K. Panati, E. Reddy, V. Narala

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引用次数: 1

摘要

血管紧张素转换酶1(ACE1)和ACE2在调节血压和电解质平衡中起重要作用。已知它们在各种组织的上皮细胞中表达。SARS-CoV2使用ACE2作为受体之一进入宿主细胞。已知冠状病毒感染相关的ACE2表达下降与血管收缩、高血压和其他心血管问题有关。服用ACE1抑制剂的患者表现出ACE2表达增加，这被认为可以保护肺免受急性肺损伤。ACE1和ACE2多态性可能与COVID-19的传染性、严重程度和恢复有关。感染人群中ACE基因多态性的关联研究可能提示COVID-19的临床结局。

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Angiotensin-converting enzyme gene polymorphism may be a risk factor for COVID-19 clinical outcome

Angiotensin-converting enzyme 1(ACE1) and ACE2 play a major role in regulation of blood pressure and electrolytic balance. They are known to express in epithelial cells of various tissues. SARS-CoV2 uses ACE2 as one of the receptors to enter into the host cells. Coronavirus infection-associated decrease in the expression of ACE2 is known to associate with vasoconstriction, hypertension and other cardiovascular problems. Patients who are on ACE1 inhibitors show increased ACE2 expression, which is known to protect the lung from acute lung injury. ACE1 and ACE2 polymorphisms might be associated with the infectivity, severity and recovery from the COVID-19. Association studies of ACE gene polymorphisms in affected population may suggest the clinical outcome of the COVID-19.

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来源期刊

Current Trends in Biotechnology and Pharmacy Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： The Association of Biotechnology and Pharmacy (ABAP) will be useful to form a forum for scientists so that they can bring together to discuss and find scientific solutions to the problems of society. The annual meetings will help the members to share their knowledge and publish their research knowledge particularly by members and fellows of the Association and special care will be taken to provide an opportunity for young scientists. Besides this the association is planned to organize symposia, seminars and workshops on current developments of Biotechnology and Pharmacy particularly on the subject of current scientific interest, and the proceedings of which will be published regularly. And in view of the vast development of science and to disseminate the problems in publication of research work, an international journal of Current Trends in Biotechnology and Pharmacy has been started by ABAP.