泛素蛋白与转录因子活性的调控

IF 6 2区 生物学 Q1 PLANT SCIENCES
Yuqi He, Kaixuan Zhang, M. Georgiev, Meiliang Zhou
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引用次数: 0

摘要

摘要泛素-蛋白酶体系统是调节靶向蛋白质降解的关键途径。一个关键步骤由E3泛素连接酶调节,它促进泛素部分转移到底物蛋白,通过26S蛋白酶体导致蛋白质降解。然而,已知的泛素依赖过程的数量仍然相对较少。由于一些与应激相关的转录因子在应激条件下通常是必不可少的,而在正常生长过程中起着负面作用,因此需要精确调节它们的蛋白质水平。然而,泛素途径、调节转录因子稳定性的机制尚未得到综述。在这篇综述中,我们试图概述E3连接酶依赖性转录因子降解的机制,并讨论E3连接酶类在植物激素信号传导中的综合作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ubiquitin Proteins and the Orchestration of Transcription Factors Activity
Abstract The ubiquitin proteasome system is a key pathway, regulating targeted proteins degradation. A critical step is regulated by E3 ubiquitin ligases, which facilitates the transfer of ubiquitin moieties to substrate proteins, leading proteins degradation via 26S proteasome. However, the number of known ubiquitin dependent processes is still relatively small. Since some stress-related transcription factors are usually essential under stress conditions, while playing negative roles during normal growth, hence their protein levels need to be precisely regulated. However, the mechanism of ubiquitin pathway, regulating transcription factors stability has not been yet summarized. In this review, we attempted to outline the mechanism of E3 ligases dependent transcription factors degradation and discuss the comprehensive role of E3 ligases in phytohormone signaling.
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来源期刊
CiteScore
12.90
自引率
1.40%
发文量
15
审稿时长
>12 weeks
期刊介绍: Critical Reviews in Plant Sciences focuses on presenting in-depth and up-to-date reviews of timely and/or cutting-edge subjects in the broad discipline of plant science, ranging from molecular biology/biochemistry through the areas of cell biology, plant pathology and physiology, genetics, classical botany, and ecology, to practical agricultural applications. Articles in the journal provide an up-to-date literature base for researchers and students, pointing the way towards future research needs. The journal is also a significant source of credible, objective information to aid decision makers at all levels.
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