富血小板血浆注射液治疗严重干眼症的疗效评估

IF 0.1 Q4 OPHTHALMOLOGY
Kareem B. Elessawy, A. Araissi, H. Nasr, S. Abdelbaky
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引用次数: 1

摘要

目的本研究旨在评估泪腺内注射富含血小板血浆(PRP)治疗严重干眼症的疗效,并与不含防腐剂的人工泪液进行比较。患者和方法本研究共纳入74眼40例患者,分为两组。干预组在泪腺区域经皮注射三次PRP。对照组采用不含防腐剂的人工泪液进行治疗。结果干预组除睑板腺评分外,所有测量参数均有改善,眼表疾病指数(OSDI)评分和Schirmer检验(P=0.011)均有统计学意义的改善,眼表面染色评分(P=0.076)和撕裂时间(TBUT)改善不太显著(P=0.09)。与对照组相比,PRP干预组的OSDI评分(P<0.001)、Schirmer检验(P=0.005)和眼表染色评分(P=0.013)均有统计学意义的改善,而TBUT的改善则不太显著(P=0.2),但对改善睑板腺功能无效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of the efficacy of platelet-rich plasma injections in the management of severe dry eye
Purpose This study aimed to assess the efficacy of a platelet-rich plasma (PRP) injection into the lacrimal gland in severe dry eye and to compare it with preservative-free artificial tears. Patients and methods This study included a total of 74 eyes of 40 patients divided into two groups. The intervention group received three PRP injections transcutaneously in the region of the lacrimal gland. The control group was treated with preservative-free artificial tears. Results The intervention group showed improvement in all measured parameters, except the Meibomian gland score, with a statistically significant improvement in the Ocular Surface Disease Index (OSDI) score (P<0.001) and the Schirmer test (P=0.011) and less significant improvement in the ocular surface staining score (P=0.076) and tear breakup time (TBUT) (P=0.09). Compared with the control group, the PRP intervention group showed a statistically significant improvement in the OSDI score (P<0.001), the Schirmer test (P=0.005) and the ocular surface staining score (P=0.013) and less significant improvement in TBUT (P=0.2). Conclusion The use of PRP injections is safe and effective, with improvement in the OSDI, Schirmer test, and ocular surface staining and less improvement in TBUT, but it is not effective in improving Meibomian gland function.
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